PROTECTIVE EFFECT OF SULFOETHYLGLUCAN AGAINST HEXAVALENT CHROMIUM

被引：32

作者：

CHORVATOVICOVA, D

KOVACIKOVA, Z

SANDULA, J

NAVAROVA, J

机构：

[1] SLOVAK ACAD SCI, INST CHEM, CS-80936 BRATISLAVA, CZECHOSLOVAKIA

[2] INST PREVENT & CLIN MED, BRATISLAVA, CZECHOSLOVAKIA

来源：

MUTATION RESEARCH | 1993年 / 302卷 / 04期

关键词：

SULFOETHYLGLUCAN; CHROMIUM (VI); MICRONUCLEUS TEST; LIVER ALKALINE PHOSPHATASE; (MICE);

D O I：

10.1016/0165-7992(93)90106-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The effect of pretreatment with sulfoethylglucan (SEG) on the frequency of micronuclei and the liver alkaline phosphatase activity induced by potassium bichromate (Cr(VI)) in mice was evaluated. Simultaneous application of SEG and Cr(VI) decreased the frequency of micronuclei in bone marrow cells (P < 0.01) and the level of liver alkaline phosphatase activity in comparison to the Cr(VI) group. Pretreatment with SEG 24 h prior to the first Cr(VI) application resulted in a more pronounced decrease in the Cr(VI)-induced frequency of micronuclei. The mechanisms of the protective effects of sulfoethylglucan could be explained either by the formation of Cr ion complexes with sulfoethyl groups of glucan or by the scavenging ability of SEG to trap hydroxyl radicals.

引用

页码：207 / 211

页数：5

共 19 条

[1] ROLE OF CHROMIUM(V), GLUTATHIONE THIYL RADICAL AND HYDROXYL RADICAL INTERMEDIATES IN CHROMIUM(VI)-INDUCED DNA DAMAGE [J].