PHILADELPHIA-CHROMOSOME-NEGATIVE PERIPHERAL-BLOOD STEM-CELLS CAN BE MOBILIZED IN THE EARLY PHASE OF RECOVERY AFTER A MYELOSUPPRESSIVE CHEMOTHERAPY IN PHILADELPHIA-CHROMOSOME-POSITIVE ACUTE LYMPHOBLASTIC-LEUKEMIA

被引：24

作者：

CARELLA, AM ^{[1
]}

FRASSONI, F ^{[1
]}

POLLICARDO, N ^{[1
]}

PUNGOLINO, E ^{[1
]}

FERRERO, R ^{[1
]}

VASALLO, F ^{[1
]}

SORACCO, M ^{[1
]}

GIORDANO, D ^{[1
]}

FIGARI, O ^{[1
]}

BENVENUTO, F ^{[1
]}

FLORIO, G ^{[1
]}

CARLIER, P ^{[1
]}

VALBONESI, M ^{[1
]}

机构：

[1] OSPED SAN MARTINO GENOVA,CTR BLOOD,GENOA,ITALY

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1995年 / 89卷 / 03期

关键词：

PH-POSITIVE ALL; BLOOD STEM CELLS; RECOVERY;

D O I：

10.1111/j.1365-2141.1995.tb08360.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ten patients in first or second relapse with Philadelphia chromosome acute lymphoblastic leukaemia, ineligible for allogeneic sibling marrow transplantation, were treated with an intensive chemotherapy regimen including idarubicin, intermediate-dose arabinosylcytosine, etoposide and G-CSF. Peripheral blood stem cells were collected by leukapheresis during initial early WBC recovery from chemotherapy-induced aplasia. In 5/10 patients all metaphases in leukapheresis products were found to be Philadelphia-chromosome-negative and they have been used as autotransplants after conditioning with TBI/etoposide/cyclophosphamide (or idarubicin) and G-CSF. All five patients showed sustained engraftment and one of them is alive and well Philadelphia-chromosome-negative 18 months after transplant. These preliminary results suggest that it is possible to recover Philadelphia-chromosome-negative blood stem cells after intensive chemotherapy, even in advanced patients, and to perform autografting with these cells.

引用

页码：535 / 538

页数：4

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