ENFLURANE REQUIREMENT AND VENTILATORY RESPONSE TO CARBON-DIOXIDE DURING LIDOCAINE INFUSION IN DOGS

被引：28

作者：

HIMES, RS ^{[1
]}

MUNSON, ES ^{[1
]}

EMBRO, WJ ^{[1
]}

机构：

[1] UNIV FLORIDA,J HILLIS MILLER HLTH CTR,COLL MED,DEPT ANESTHESIOL,GAINESVILLE,FL 32610

来源：

ANESTHESIOLOGY | 1979年 / 51卷 / 02期

关键词：

D O I：

10.1097/00000542-197908000-00008

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Arterial plasma lidocaine concentrations of 1 to 3.5 μg/ml produced dose-related decreases in enflurane requirement (MAC) ranging from 15 to 37% in dogs. The ventilatory responses to carbon dioxide at comparable depths of anesthesia with enflurane alone and the enflurane-lidocaine combination were measured in each animal and compared. With both anesthetic regimens there were increases in resting arterial carbon dioxide tension (mean maximal increase = 18 torr) and a 69% decrease in the slope of the ventilatory response as depth of anesthesia increased. The effect of the drug interaction appears to be additive, since the ventilatory depression produced by the enflurane-lidocaine combination was no greater than that produced by enflurane alone at equivalent levels of anesthesia.

引用

页码：131 / 134

页数：4