G-PROTEIN CASCADES - GAIN AND KINETICS

被引：86

作者：

LAMB, TD

PUGH, EN

机构：

[1] UNIV PENN,DEPT PSYCHOL,PHILADELPHIA,PA 19104

[2] UNIV PENN,INST NEUROL SCI,PHILADELPHIA,PA 19104

来源：

TRENDS IN NEUROSCIENCES | 1992年 / 15卷 / 08期

关键词：

D O I：

10.1016/0166-2236(92)90079-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

G-protein cascades provide amplification in a wide variety of biological signal transducers - from hormonal and synaptic systems to the receptor cells of vision and olfaction. Through recent understanding of the molecular mechanisms involved, it is possible to construct a quantitative description of the amplification and speed of response of the cascade. The gain and kinetics can now be described in terms of physical parameters, such as enzyme activities and the densities and lateral diffusion coefficients of the proteins involved.

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页码：291 / 298

页数：8

相关论文

共 39 条

[1] RECEPTOR-EFFECTOR COUPLING BY G-PROTEINS [J].

BIRNBAUMER, L ;

ABRAMOWITZ, J ;

BROWN, AM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1031 (02) :163-224

[2]

BRETON ME, 1992, INVEST OPHTH VIS SCI, V33, P1407

[3] IONIC CHANNELS AND THEIR REGULATION BY G-PROTEIN SUBUNITS [J].

BROWN, AM ;

BIRNBAUMER, L .

ANNUAL REVIEW OF PHYSIOLOGY, 1990, 52 :197-213

[4] A NOVEL MULTIGENE FAMILY MAY ENCODE ODORANT RECEPTORS - A MOLECULAR-BASIS FOR ODOR RECOGNITION [J].

BUCK, L ;

AXEL, R .

CELL, 1991, 65 (01) :175-187

[5]

CHABRE M, 1990, G PROTEINS, P215

[6] KINETICS AND COMPONENTS OF THE FLASH PHOTOCURRENT OF ISOLATED RETINAL RODS OF THE LARVAL SALAMANDER, AMBYSTOMA-TIGRINUM [J].

COBBS, WH ;

PUGH, EN .

JOURNAL OF PHYSIOLOGY-LONDON, 1987, 394 :529-572

[7] CGMP PHOSPHODIESTERASE OF RETINAL RODS IS REGULATED BY 2 INHIBITORY SUBUNITS [J].

DETERRE, P ;

BIGAY, J ;

FORQUET, F ;

ROBERT, M ;

CHABRE, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (08) :2424-2428

[8] PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION OF A CYCLIC NUCLEOTIDE-ACTIVATED CHANNEL FROM OLFACTORY NEURONS [J].

DHALLAN, RS ;

YAU, KW ;

SCHRADER, KA ;

REED, RR .

NATURE, 1990, 347 (6289) :184-187

[9] REGULATION OF CALCIUM-CHANNEL ACTIVITY BY GTP BINDING-PROTEINS AND 2ND MESSENGERS [J].

DOLPHIN, AC .

BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1091 (01) :68-80

[10] INDUCTION BY CYCLIC-GMP OF CATIONIC CONDUCTANCE IN PLASMA-MEMBRANE OF RETINAL ROD OUTER SEGMENT [J].

FESENKO, EE ;

KOLESNIKOV, SS ;

LYUBARSKY, AL .

NATURE, 1985, 313 (6000) :310-313

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