G-PROTEIN CASCADES - GAIN AND KINETICS

被引：86

作者：

LAMB, TD

PUGH, EN

机构：

[1] UNIV PENN,DEPT PSYCHOL,PHILADELPHIA,PA 19104

[2] UNIV PENN,INST NEUROL SCI,PHILADELPHIA,PA 19104

来源：

TRENDS IN NEUROSCIENCES | 1992年 / 15卷 / 08期

关键词：

D O I：

10.1016/0166-2236(92)90079-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

G-protein cascades provide amplification in a wide variety of biological signal transducers - from hormonal and synaptic systems to the receptor cells of vision and olfaction. Through recent understanding of the molecular mechanisms involved, it is possible to construct a quantitative description of the amplification and speed of response of the cascade. The gain and kinetics can now be described in terms of physical parameters, such as enzyme activities and the densities and lateral diffusion coefficients of the proteins involved.

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页码：291 / 298

页数：8

相关论文

共 39 条

[11] TIME COURSE OF THE MEMBRANE CURRENT UNDERLYING SENSORY TRANSDUCTION IN SALAMANDER OLFACTORY RECEPTOR NEURONS [J].

FIRESTEIN, S ;

SHEPHERD, GM ;

WERBLIN, FS .

JOURNAL OF PHYSIOLOGY-LONDON, 1990, 430 :135-158

[12] A NOSEFULL OF ODOR RECEPTORS [J].

FIRESTEIN, S .

TRENDS IN NEUROSCIENCES, 1991, 14 (07) :270-272

[13] KINETICS OF PHOTOTRANSDUCTION IN RETINAL RODS OF THE NEWT TRITURUS-CRISTATUS [J].

FORTI, S ;

MENINI, A ;

RISPOLI, G ;

TORRE, V .

JOURNAL OF PHYSIOLOGY-LONDON, 1989, 419 :265-295

[14]

Gillespie P.G., 1990, CYCLIC NUCLEOTIDE PH, P163

[15] LATERAL DIFFUSION OF VISUAL PIGMENTS IN TOAD (BUFO-MARINUS) RODS AND IN CATFISH (ICTALURUS-PUNCTATUS) CONES [J].

GUPTA, BD ;

WILLIAMS, TP .

JOURNAL OF PHYSIOLOGY-LONDON, 1990, 430 :483-496

[16] A MONOCLONAL-ANTIBODY TO GUANINE-NUCLEOTIDE BINDING-PROTEIN INHIBITS THE LIGHT-ACTIVATED CYCLIC-GMP PATHWAY IN FROG ROD OUTER SEGMENTS [J].

HAMM, HE ;

BOWNDS, MD .

JOURNAL OF GENERAL PHYSIOLOGY, 1984, 84 (02) :265-280

[17] ADENYLATE-CYCLASE ACTIVATION BY THE BETA-ADRENERGIC RECEPTORS AS A DIFFUSION-CONTROLLED PROCESS [J].

HANSKI, E ;

RIMON, G ;

LEVITZKI, A .

BIOCHEMISTRY, 1979, 18 (05) :846-853

[18]

HARGRAVE PA, 1992, SIGNAL TRANSDUCTION

[19] CONTROL OF LIGHT-SENSITIVE CURRENT IN SALAMANDER RODS [J].

HODGKIN, AL ;

NUNN, BJ .

JOURNAL OF PHYSIOLOGY-LONDON, 1988, 403 :439-471

[20] GOLF - AN OLFACTORY NEURON SPECIFIC G-PROTEIN INVOLVED IN ODORANT SIGNAL TRANSDUCTION [J].

JONES, DT ;

REED, RR .

SCIENCE, 1989, 244 (4906) :790-795

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