REGIONAL IMPAIRMENT OF MUCOCILIARY CLEARANCE IN CHRONIC OBSTRUCTIVE PULMONARY-DISEASE

被引:74
作者
SMALDONE, GC
FOSTER, WM
ORIORDAN, TG
MESSINA, MS
PERRY, RJ
LANGENBACK, EG
机构
[1] Pulmonary Disease Division, SUNY Health Science Center, Stony Brook
关键词
D O I
10.1378/chest.103.5.1390
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Asthmatic subjects with tidal expiratory flow limitation have mucociliary clearance (MC) impairment in central airways, Because tidal flow limitation develops in COPD, it is possible that regional MC in these patients also may be affected. We tested this hypothesis by measuring MC in the presence or absence of flow limitations. Patients with COPD and chronic flow limitation were compared with non-flow-limited normal volunteers. Deposition was normalized for regional lung volume and expressed as the specific central to peripheral (sC/P) ratio. In COPD subjects, clearance from the whole lung and central airways was significantly different from that of normal subjects after 20 min of observation. In the peripheral airways, there were no significant differences between COPD and normal subjects. An alternative analysis of regional MC indicated patients retained particles in central airways while normal subjects, with intact MC, emptied central airways. Thus, COPD subjects with tidal expiratory flow limitation have im aired MC in their central airways.
引用
收藏
页码:1390 / 1396
页数:7
相关论文
共 28 条
[11]   DEPOSITION AND CLEARANCE OF 2 MU PARTICLES IN TRACHEOBRONCHIAL TREE OF NORMAL SUBJECTS - SMOKERS AND NONSMOKERS [J].
LOURENCO, RV ;
KLIMEK, MF ;
BOROWSKI, CJ .
JOURNAL OF CLINICAL INVESTIGATION, 1971, 50 (07) :1411-&
[12]   BRONCHIAL PRESSURES AND DIMENSIONS IN HEALTH AND OBSTRUCTUVE AIRWAY DISEASE [J].
MACKLEM, PT ;
BATES, DV ;
FRASER, RG .
JOURNAL OF APPLIED PHYSIOLOGY, 1963, 18 (04) :699-&
[13]  
MACKLEM PT, 1965, MED THORAC, V22, P220
[14]  
MOSSBERG B, 1976, SCAND J RESPIR DIS, V57, P281
[15]   MUCOCILIARY CLEARANCE IN ADULT ASTHMA [J].
ORIORDAN, TG ;
ZWANG, J ;
SMALDONE, GC .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 146 (03) :598-603
[16]  
PUCHELLE E, 1979, SCAND J RESPIR DIS, V60, P307
[17]   FLOW LIMITATION, COUGH, AND PATTERNS OF AEROSOL DEPOSITION IN HUMANS [J].
SMALDONE, GC ;
MESSINA, MS .
JOURNAL OF APPLIED PHYSIOLOGY, 1985, 59 (02) :515-520
[18]   LOCATION OF FLOW-LIMITING SEGMENTS VIA AIRWAY CATHETERS NEAR RESIDUAL VOLUME IN HUMANS [J].
SMALDONE, GC ;
SMITH, PL .
JOURNAL OF APPLIED PHYSIOLOGY, 1985, 59 (02) :502-508
[19]  
SMALDONE GC, 1979, AM REV RESPIR DIS, V120, P747
[20]   ENHANCEMENT OF PARTICLE DEPOSITION BY FLOW-LIMITING SEGMENTS IN HUMANS [J].
SMALDONE, GC ;
MESSINA, MS .
JOURNAL OF APPLIED PHYSIOLOGY, 1985, 59 (02) :509-514