A RETROSPECTIVE ANALYSIS OF TREATMENT OUTCOME IN 106 CASES OF LOCALIZED GASTRIC NON-HODGKIN LYMPHOMAS

被引：29

作者：

BRINCKER, H

DAMORE, F

机构：

[1] Department of Hematology, Odense University Hospital

来源：

LEUKEMIA & LYMPHOMA | 1995年 / 18卷 / 3-4期

关键词：

POPULATION-BASED; GASTRIC LYMPHOMA; PROGNOSTIC FACTORS; SURGERY; RADIOTHERAPY; COMPLICATIONS;

D O I：

10.3109/10428199509059619

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

197 cases of gastric lymphoma were reported to a population-based Danish registry of non-Hodgkin's lymphomas. 106 of these cases were localized, representing stages IE and II(1)E, and were analyzed retrospectively, using Cox regression analysis, 67 had surgical resection, 51 chemotherapy, and 55 radiotherapy, or combinations thereof. No type of treatment showed any superiority as regards survival (p = 0.13). Overall 5-year survival was 67%. The pretherapeutic presence of fever or S-LDH-elevation had a far more significant influence on survival than histology or any of the treatments or treatment combinations. Surgical resection was associated with a significantly higher risk of late complications than radiotherapy, suggesting that radiotherapy may be preferable to surgery as the primary treatment in localized gastric lymphoma. It could not be determined from the available data whether the addition of chemotherapy to the primary treatment provides any survival benefit.

引用

页码：281 / 288

页数：8

共 35 条

[11]

Cox D.R., Regression models and life tables, J. Roy. Statist. Soc, 34, pp. 187-220, (1972)

[12]

Herrmann R., Panahon A.M., Barcos M.P., Walsh D., Stuzman L., Gastrointestinal involvement in non-Hodgkin's lymphoma, Cancer, 46, pp. 215-222, (1980)

[13]

Shiu M.H., Karas M., Nisce L., Lee B.J., Filippa D.A., Lieberman P.H., Management of primary gastric lymphoma, Ann. Surg., 195, pp. 196-202, (1982)

[14]

Weingrad D.N., Decosse J.J., Sherlock P., Straus D., Lieberman P.H., Filippa D.A., Primary gastrointestinal lymphoma: A 30-year review, Cancer, 49, pp. 1258-1265, (1982)

[15]

Filippa D.A., Decosse J.J., Lieberman P.H., Bretsky S.S., Weingrad D.N., Primary lymphomas of the gastrointestinal tract. Analysis of prognostic factors with emphasis on histological type, Am. J. Surg. Path., 7, pp. 363-372, (1983)

[16]

Hockey M.S., Powell J., Crocker J., Fielding J.W.L., Primary gastric lymphoma, Br. J. Surg., 74, pp. 483-487, (1987)

[17]

Mirza M.R., Brincker H., Specht L., The integration of radiotherapy into the primary treatment of non-Hodgkin's lymphoma, Crit. Rew. Oncol. Hematol., 12, pp. 217-229, (1992)

[18]

Snoddy W.T., Primary lymphosarcoma of the stomach, Gastroenterol., 20, pp. 537-553, (1952)

[19]

Redd B.L., Lymphosarcoma of the stomach. Review and case reports, Am. J. Roentgenol., 82, pp. 450-634, (1959)

[20]

Bush R.S., Ash C.L., Primary lymphoma of the gastrointestinal tract, Radiol., 92, pp. 1349-1354, (1969)

← 1 2 3 4 →