5-HYDROXYTRYPTAMINE RECEPTOR CHARACTERIZATION OF HUMAN CEREBRAL, MIDDLE MENINGEAL AND TEMPORAL ARTERIES - REGIONAL DIFFERENCES

被引:44
作者
JANSEN, I
OLESEN, J
EDVINSSON, L
机构
[1] GENTOFTE HOSP,DEPT NEUROMED,DK-2900 COPENHAGEN,DENMARK
[2] UNIV LUND HOSP,DEPT INTERNAL MED,S-22185 LUND,SWEDEN
来源
ACTA PHYSIOLOGICA SCANDINAVICA | 1993年 / 147卷 / 02期
关键词
5-HYDROXYTRYPTAMINE; VASOMOTOR RESPONSES; HUMAN CRANIAL ARTERIES;
D O I
10.1111/j.1748-1716.1993.tb09483.x
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We have studied the regional distribution of 5-hydroxytryptamine (5-HT) receptor subtypes in fresh circular segments of human cerebral, middle meningeal, and temporal arteries. Vasomotor responses induced by a series of 5-HT agonists and antagonists with some degree of selectivity were studied by using a sensitive in vitro system. Nine 5-HT agonists were examined for contractile effects on the arteries. In cerebral and meningeal arteries 5-carboxamidotryptamine (5-CT) was more potent than 5-HT. The opposite order of potency (5-HT-5-CT) was found in temporal arteries. In the cerebral arteries 5-methoxytryptamin (5-MeOHT) was more potent than sumatriptan while sumatriptan was more potent than 5-MeOHT in meningeal and temporal arteries. The 5-HT1 receptor antagonist, methiothepin, competitively antagonized 5-CT-induced contractions in cerebral arteries, with a pA2 value of 9.05. 5-HT-induced contractions were competitively antagonized by ketanserin (5-HT2) in the temporal arteries pA2 value of 9.06). Methiothepin and ketanserin had non-competitive antagonistic effects in the middle meningeal arteries. The 5-HT3 selective antagonist ondansetron did not cause any shift of the contractions induced by 2-methyl-5-HT in the temporal, cerebral and middle meningeal arteries. These results suggest that the cerebral arteries mainly contain 5-HT1D or 5-HT1-like receptors, and the temporal artery 5-HT2 receptors; the data further indicate the presence of both receptor subtypes in the middle meningeal artery.
引用
收藏
页码:141 / 150
页数:10
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