INSULIN-LIKE GROWTH FACTOR-I AND INSULIN AS GROWTH AND DIFFERENTIATION FACTORS IN CHICKEN EMBRYOGENESIS

被引：22

作者：

DEPABLO, F ^{[1
]}

ROBCIS, HL ^{[1
]}

CALDES, T ^{[1
]}

ALEMANY, J ^{[1
]}

SCAVO, L ^{[1
]}

SERRANO, J ^{[1
]}

机构：

[1] NIH,NATL CTR RES RESOURCES,VET RESOURCES PROGRAM,BETHESDA,MD 20892

来源：

POULTRY SCIENCE | 1991年 / 70卷 / 08期

关键词：

INSULIN-LIKE GROWTH FACTOR-I; INSULIN; RECEPTORS; DEVELOPMENT; CHICKEN EMBRYO;

D O I：

10.3382/ps.0701790

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

The avian embryo has been a useful model system for studies on the role of insulin and its close relative insulin-like growth factor-I (IGF-I) in development. The unfertilized chicken egg contains both peptides from maternal origin, and the embryo expresses insulin and IGF-I before the major organs are formed. Insulin receptors and IGF-I receptors are found in the blastoderm and in all tissues examined during organogenesis. When exogenous insulin or IGF-I are added to the embryo, growth and differentiation events are stimulated. By contrast, insulin antibodies and insulin receptor antibodies retard embryo development. In embryos cultured ex ovo, in which growth is impaired, the levels of serum IGF-I are decreased.

引用

页码：1790 / 1796

页数：7

共 17 条

[1] TRANSCRIPTIONAL STIMULATION OF THE DELTA-1-CRYSTALLIN GENE BY INSULIN-LIKE GROWTH FACTOR-I AND INSULIN REQUIRES DNA CIS ELEMENTS IN CHICKEN [J].

ALEMANY, J ;

BORRAS, T ;

DEPABLO, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (09) :3353-3357

[2]

ALEMANY J, 1989, J BIOL CHEM, V264, P17559

[3] DEVELOPMENTAL REGULATION OF INSULIN AND TYPE-I INSULIN-LIKE GROWTH-FACTOR RECEPTORS AND ABSENCE OF TYPE-II RECEPTORS IN CHICKEN-EMBRYO TISSUES [J].

BASSAS, L ;

LESNIAK, MA ;

SERRANO, J ;

ROTH, J ;

DEPABLO, F .

DIABETES, 1988, 37 (05) :637-644

[4] DEVELOPMENT OF RECEPTORS FOR INSULIN AND INSULIN-LIKE GROWTH FACTOR-I IN HEAD AND BRAIN OF CHICK-EMBRYOS - AUTORADIOGRAPHIC LOCALIZATION [J].

BASSAS, L ;

GIRBAU, M ;

LESNIAK, MA ;

ROTH, J ;

DEPABLO, F .

ENDOCRINOLOGY, 1989, 125 (05) :2320-2327

[5] THE INSULIN-RECEPTORS OF CHICK-EMBRYO SHOW TISSUE-SPECIFIC STRUCTURAL DIFFERENCES WHICH PARALLEL THOSE OF THE INSULIN-LIKE GROWTH FACTOR-I RECEPTORS [J].

BASSAS, L ;

DEPABLO, F ;

LESNIAK, MA ;

ROTH, J .

ENDOCRINOLOGY, 1987, 121 (04) :1468-1476

[6] LENTROPIN, A PROTEIN THAT CONTROLS LENS FIBER FORMATION, IS RELATED FUNCTIONALLY AND IMMUNOLOGICALLY TO THE INSULIN-LIKE GROWTH-FACTORS [J].

BEEBE, DC ;

SILVER, MH ;

BELCHER, KS ;

VANWYK, JJ ;

SVOBODA, ME ;

ZELENKA, PS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (08) :2327-2330

[7] INSULIN-LIKE GROWTH FACTOR-I AND FACTOR-II - PEPTIDE, MESSENGER RIBONUCLEIC-ACID AND GENE STRUCTURES, SERUM, AND TISSUE CONCENTRATIONS [J].

DAUGHADAY, WH ;

ROTWEIN, P .

ENDOCRINE REVIEWS, 1989, 10 (01) :68-91

[8] INSULIN-ANTIBODIES RETARD AND INSULIN ACCELERATES GROWTH AND DIFFERENTIATION IN EARLY EMBRYOS [J].

DEPABLO, F ;

GIRBAU, M ;

GOMEZ, JA ;

HERNANDEZ, E ;

ROTH, J .

DIABETES, 1985, 34 (10) :1063-1067

[9] INSULIN IS PRESENT IN CHICKEN EGGS AND EARLY CHICK-EMBRYOS [J].

DEPABLO, F ;

ROTH, J ;

HERNANDEZ, E ;

PRUSS, RM .

ENDOCRINOLOGY, 1982, 111 (06) :1909-1916

[10] INSULIN AND INSULIN-LIKE GROWTH FACTOR-I IN EARLY DEVELOPMENT - PEPTIDES, RECEPTORS AND BIOLOGICAL EVENTS [J].

DEPABLO, F ;

SCOTT, LA ;

ROTH, J .

ENDOCRINE REVIEWS, 1990, 11 (04) :558-577

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