INSULIN-LIKE GROWTH FACTOR-I AND INSULIN AS GROWTH AND DIFFERENTIATION FACTORS IN CHICKEN EMBRYOGENESIS

被引：22

作者：

DEPABLO, F ^{[1
]}

ROBCIS, HL ^{[1
]}

CALDES, T ^{[1
]}

ALEMANY, J ^{[1
]}

SCAVO, L ^{[1
]}

SERRANO, J ^{[1
]}

机构：

[1] NIH,NATL CTR RES RESOURCES,VET RESOURCES PROGRAM,BETHESDA,MD 20892

来源：

POULTRY SCIENCE | 1991年 / 70卷 / 08期

关键词：

INSULIN-LIKE GROWTH FACTOR-I; INSULIN; RECEPTORS; DEVELOPMENT; CHICKEN EMBRYO;

D O I：

10.3382/ps.0701790

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

The avian embryo has been a useful model system for studies on the role of insulin and its close relative insulin-like growth factor-I (IGF-I) in development. The unfertilized chicken egg contains both peptides from maternal origin, and the embryo expresses insulin and IGF-I before the major organs are formed. Insulin receptors and IGF-I receptors are found in the blastoderm and in all tissues examined during organogenesis. When exogenous insulin or IGF-I are added to the embryo, growth and differentiation events are stimulated. By contrast, insulin antibodies and insulin receptor antibodies retard embryo development. In embryos cultured ex ovo, in which growth is impaired, the levels of serum IGF-I are decreased.

引用

页码：1790 / 1796

页数：7

共 17 条

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