ARYLAMINE SPIDER TOXINS ANTAGONIZE NMDA RECEPTOR-MEDIATED SYNAPTIC TRANSMISSION IN RAT HIPPOCAMPAL SLICES

被引:19
作者
MUELLER, AL [1 ]
ALBENSI, BC [1 ]
GANONG, AH [1 ]
REYNOLDS, LS [1 ]
JACKSON, H [1 ]
机构
[1] PFIZER INC, DIV CENT RES, GROTON, CT 06340 USA
关键词
ARGIOTOXINS; GLUTAMATE RECEPTORS; AMPA;
D O I
10.1002/syn.890090403
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effects of arylamine spider toxins on synaptic transmission in rat hippocampal slices were investigated. Two different responses were monitored: the AMPA receptor-mediated population spike recorded in control buffer (selectively antagonized by DNQX) and the NMDA receptor-mediated EPSP recorded in nominally magnesium-free buffer containing 20-mu-M DNQX (selectively antagonized by AP5, AP7, and dizocilpine (MK-801)). The synthetic arylamine spider toxins JSTX-3, argiotoxin-636, and argiotoxin-659 were 26 to 73 times more potent at antagonizing the NMDA receptor-mediated EPSP (IC50 values ranging from 12 to 24-mu-M) than the AMPA receptor-mediated population spike (IC50 values ranging from 612 to 878-mu-M). These results indicate that arylamine spider toxins are selective antagonists of NMDA receptors in the mammalian CNS.
引用
收藏
页码:244 / 250
页数:7
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