ARYLAMINE SPIDER TOXINS ANTAGONIZE NMDA RECEPTOR-MEDIATED SYNAPTIC TRANSMISSION IN RAT HIPPOCAMPAL SLICES

被引：19

作者：

MUELLER, AL ^{[1
]}

ALBENSI, BC ^{[1
]}

GANONG, AH ^{[1
]}

REYNOLDS, LS ^{[1
]}

JACKSON, H ^{[1
]}

机构：

[1] PFIZER INC, DIV CENT RES, GROTON, CT 06340 USA

来源：

SYNAPSE | 1991年 / 9卷 / 04期

关键词：

ARGIOTOXINS; GLUTAMATE RECEPTORS; AMPA;

D O I：

10.1002/syn.890090403

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of arylamine spider toxins on synaptic transmission in rat hippocampal slices were investigated. Two different responses were monitored: the AMPA receptor-mediated population spike recorded in control buffer (selectively antagonized by DNQX) and the NMDA receptor-mediated EPSP recorded in nominally magnesium-free buffer containing 20-mu-M DNQX (selectively antagonized by AP5, AP7, and dizocilpine (MK-801)). The synthetic arylamine spider toxins JSTX-3, argiotoxin-636, and argiotoxin-659 were 26 to 73 times more potent at antagonizing the NMDA receptor-mediated EPSP (IC50 values ranging from 12 to 24-mu-M) than the AMPA receptor-mediated population spike (IC50 values ranging from 612 to 878-mu-M). These results indicate that arylamine spider toxins are selective antagonists of NMDA receptors in the mammalian CNS.

引用

页码：244 / 250

页数：7

共 29 条

[11] SPIDER TOXINS - RECENT APPLICATIONS IN NEUROBIOLOGY [J].