BACKBONE MODIFIED FORMYL-METHIONYL TRIPEPTIDE CHEMOATTRACTANTS

被引：24

作者：

FORMAGGIO, F

PANTANO, M

CRISMA, M

TONIOLO, C

BOESTEN, WHJ

SCHOEMAKER, HE

KAMPHUIS, J

BECKER, EL

机构：

[1] UNIV PADUA,CNR,DEPT ORGAN CHEM,BIOPOLYMER RES CTR,I-35131 PADUA,ITALY

[2] DSM RES & PATENTS,BIOORGAN CHEM SECT,6160 MD GELEEN,NETHERLANDS

[3] UNIV CONNECTICUT,CTR HLTH,DEPT PATHOL,FARMINGTON,CT 06032

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(00)80699-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The conformationally restricted tripeptides HCO-L-Met-Xxx-L-Phe-OMe [where Xxx is L (D)-Iva, -(alphaMe)Val or -(alphaMe)Phe] were synthesized and tested for their beta-glucosaminidase release activity. The [L-(alphaMe)Val]2- and [L-(alphaMe)Leu]2- analogues turned out to be the most active compounds examined. The positive effects induced by increasing side-chain hydrophobicity and by the L-chirality of the Xxx residue on peptide-receptor interactions are discussed.

引用

页码：953 / 956

页数：4

共 5 条

[1] FORMYL PEPTIDE CHEMOATTRACTANTS - A MODEL OF THE RECEPTOR ON RABBIT NEUTROPHILS [J].