IMMUNOSUPPRESSION BY ULTRAVIOLET-B RADIATION - INITIATION BY UROCANIC ACID

被引：236

作者：

NOONAN, FP

DEFABO, EC

机构：

[1] Frances P. Noonan and Edward C. De Fabo are, the Laboratory of Photoimmunology and Photobiology, Dept of Dermatology, Washington

来源：

IMMUNOLOGY TODAY | 1992年 / 13卷 / 07期

关键词：

D O I：

10.1016/0167-5699(92)90005-R

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Irradiation with UV-B, a component of natural sunlight, initiates systemic immunosuppression of delayed-type hypersensitivity responses. This may be a fundamental regulatory mechanism, controlling the interaction between mammals and potentially deleterious environmental UV radiation. Here, Frances Noonan and Edward De Fabo assess the evidence that suppression is initiated by the photoisomerization of trans-urocanic acid (UCA) in the stratum corneum, discuss the significance of this mechanism for skin cancer outgrowth and propose applications for UCA in transplantation.

引用

页码：250 / 254

页数：5

共 46 条

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