NATURALLY-OCCURRING LINEAR FUSED THIAZOLINE-THIAZOLE CONTAINING METABOLITES - TOTAL SYNTHESIS OF (-)-DIDEHYDROMIRABAZOLE-A, A CYTOTOXIC ALKALOID FROM BLUE-GREEN-ALGAE

被引：42

作者：

PATTENDEN, G

THOM, SM

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 14期

关键词：

D O I：

10.1039/p19930001629

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise total synthesis of the thiazoline-thiazole containing metabolite didehydromirabazole A 1 is described. The synthesis uses the unusual amino acid (R)-2-methylcysteine 20 in sequential cyclocondensations with imino ethers as key steps, viz 22 --> 32 and 37 --> 38.

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页码：1629 / 1636

页数：8

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