SOLUBLE C-ERBB-2 FRAGMENT IN SERUM CORRELATES WITH DISEASE STAGE AND PREDICTS FOR SHORTENED SURVIVAL IN PATIENTS WITH EARLY-STAGE AND ADVANCED BREAST-CANCER

被引：80

作者：

KANDL, H ^{[1
]}

SEYMOUR, L ^{[1
]}

BEZWODA, WR ^{[1
]}

机构：

[1] UNIV WITWATERSRAND,SCH MED,DEPT MED,DIV CLI HAEMATOL & MED ONCOL,JOHANNESBURG 2193,SOUTH AFRICA

来源：

BRITISH JOURNAL OF CANCER | 1994年 / 70卷 / 04期

关键词：

D O I：

10.1038/bjc.1994.387

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Seventy-nine patients with advanced breast cancer were tested for the presence, in serum, of a 110 kDa soluble, c-erbB-2 fragment. Thirty-nine patients were seropositive. There was no correlation between seropositivity and menopausal status, or with oestrogen status. In addition, no correlation could be found between tissue c-erbB-2 immunostaining for the external domain of the c-erbB-2 receptor and the presence of soluble c-erbB-2 in serum. The presence of serum soluble c-erbB-2, however, had a significant impact on survival of patients with advanced disease, suggesting that this test may become a useful independent prognostic indicator.

引用

页码：739 / 742

页数：4