NMDAR1 MESSENGER-RNA EXPRESSION IN THE BRAIN-STEM CIRCUIT CONTROLLING ESOPHAGEAL PERISTALSIS

被引：34

作者：

BROUSSARD, DL

WIEDNER, EB

LI, X

ALTSCHULER, SM

机构：

[1] Division of Gastroenterology and Nutrition, Children's Hospital of Philadelphia, Department of Pediatrics, Philadelphia, PA 19104

来源：

MOLECULAR BRAIN RESEARCH | 1994年 / 27卷 / 02期

基金：

美国国家卫生研究院;

关键词：

NMDA RECEPTOR; NUCLEUS TRACTUS SOLITARII; NUCLEUS AMBIGUUS; PSEUDORABIES VIRUS; IN SITU HYBRIDIZATION; IMMUNOHISTOCHEMISTRY; ESOPHAGEAL PERISTALSIS;

D O I：

10.1016/0169-328X(94)90018-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the expression of NMDA receptors within the brainstem circuit controlling esophageal swallowing using transneuronal viral labeling and in situ hybridization. Neurons of the central subnucleus of the nucleus solitary tract (NTScen) are interneurons linking vagal afferents with esophageal motoneurons in the compact formation of the nucleus ambiguus (NAc). Following injections of Pseudorabies virus (PRV) into rat esophagus and incubation with NMDAR1 cRNA, neurons infected with PRV localized to the NA(c) and NTScen expressed NMDAR1 mRNA.

引用

页码：329 / 332

页数：4

共 21 条

[1] DENDRITIC ARCHITECTURE OF NUCLEUS AMBIGUUS MOTONEURONS PROJECTING TO THE UPPER ALIMENTARY-TRACT IN THE RAT [J].

ALTSCHULER, SM ;

BAO, XM ;

MISELIS, RR .

JOURNAL OF COMPARATIVE NEUROLOGY, 1991, 309 (03) :402-414

[2] VISCEROTOPIC REPRESENTATION OF THE UPPER ALIMENTARY-TRACT IN THE RAT - SENSORY GANGLIA AND NUCLEI OF THE SOLITARY AND SPINAL TRIGEMINAL TRACTS [J].

ALTSCHULER, SM ;

BAO, X ;

BIEGER, D ;

HOPKINS, DA ;

MISELIS, RR .

JOURNAL OF COMPARATIVE NEUROLOGY, 1989, 283 (02) :248-268

[3] BRAIN-STEM LOCALIZATION OF RODENT ESOPHAGEAL PREMOTOR NEURONS REVEALED BY TRANSNEURONAL PASSAGE OF PSEUDORABIES VIRUS [J].

BARRETT, RT ;

BAO, XM ;

MISELIS, RR ;

ALTSCHULER, SM .

GASTROENTEROLOGY, 1994, 107 (03) :728-737

[4] NITRIC-OXIDE, A NOVEL NEURONAL MESSENGER [J].

BREDT, DS ;

SNYDER, SH .

NEURON, 1992, 8 (01) :3-11

[5] THE EXPRESSION OF A NMDA RECEPTOR GENE IN GUINEA-PIG MYENTERIC PLEXUS [J].

BROUSSARD, DL ;

LI, XS ;

PRITCHETT, DB ;

LYNCH, D ;

BANNERMANN, PGC ;

PLEASURE, D .

NEUROREPORT, 1994, 5 (08) :973-976

[6]

CUNNINGHAM E T JR, 1990, Dysphagia, V5, P35, DOI 10.1007/BF02407391

[7] THE NO HYPOTHESIS - POSSIBLE EFFECTS OF A SHORT-LIVED, RAPIDLY DIFFUSIBLE SIGNAL IN THE DEVELOPMENT AND FUNCTION OF THE NERVOUS-SYSTEM [J].

GALLY, JA ;

MONTAGUE, PR ;

REEKE, GN ;

EDELMAN, GM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (09) :3547-3551

[8] EXCITATORY AMINO-ACID RECEPTOR-MEDIATED ACTIVATION OF SOLITARIAL DEGLUTITIVE LOCI [J].

HASHIM, MA ;

BIEGER, D .

NEUROPHARMACOLOGY, 1989, 28 (09) :913-921

[9] THE PROPORTION OF GALANIN-IMMUNOREACTIVE NEURONS IN MOUSE TRIGEMINAL GANGLIA IS TRANSIENTLY INCREASED FOLLOWING CORNEAL INOCULATION OF HERPES-SIMPLEX VIRUS TYPE-1 [J].

HENKEN, DB ;

MARTIN, JR .

NEUROSCIENCE LETTERS, 1992, 140 (02) :177-180

[10]

ISHII T, 1993, J BIOL CHEM, V268, P2836

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