DISCOVERY OF A NOVEL CLASS OF ORALLY ACTIVE, NONPEPTIDE ANGIOTENSIN-II ANTAGONISTS

被引：45

作者：

DE, B ^{[1
]}

WINN, M ^{[1
]}

ZYDOWSKY, TM ^{[1
]}

KERKMAN, DJ ^{[1
]}

DEBERNARDIS, JF ^{[1
]}

LEE, J ^{[1
]}

BUCKNER, S ^{[1
]}

WARNER, R ^{[1
]}

BRUNE, M ^{[1
]}

HANCOCK, A ^{[1
]}

OPGENORTH, T ^{[1
]}

MARSH, K ^{[1
]}

机构：

[1] ABBOTT LABS,DIV CARDIOVASC RES,DIV PHARMACEUT PROD,ABBOTT PK,IL 60064

来源：

关键词：

D O I：

10.1021/jm00098a018

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3714 / 3717

页数：4

共 24 条

[1] ALDRICH PE, 1989, Patent No. 4870186
[2] SYNTHESEN IN DER HETEROCYCLISCHEN REIHE .1. NEUE SYNTHESEN 5-MONOSUBSTITUIERTER PYRIMIDINE
BREDERECK, H
EFFENBERGER, F
SCHWEIZER, EH
[J]. CHEMISCHE BERICHTE-RECUEIL, 1962, 95 (03): : 803 - &
[3] CANGIANO JL, 1979, J PHARMACOL EXP THER, V208, P310
[4] CHANG RSL, 1990, MOL PHARMACOL, V29, P347
[5] IDENTIFICATION OF ANGIOTENSIN-II RECEPTOR SUBTYPES
CHIU, AT
HERBLIN, WF
MCCALL, DE
ARDECKY, RJ
CARINI, DJ
DUNCIA, JV
PEASE, LJ
WONG, PC
WEXLER, RR
JOHNSON, AL
TIMMERMANS, PBMWM
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 165 (01) : 196 - 203
[6] NON-PEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS .2. PHARMACOLOGY OF S-8308
CHIU, AT
CARINI, DJ
JOHNSON, AL
MCCALL, DE
PRICE, WA
THOOLEN, MJMC
WONG, PC
TABER, RI
TIMMERMANS, PBMWM
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 157 (01) : 13 - 21
[7] DELEAN A, 1984, MOL PHARMACOL, V26, P498
[8] THE DISCOVERY OF DUP-753, A POTENT, ORALLY ACTIVE NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONIST
DUNCIA, JV
CARINI, DJ
CHIU, AT
JOHNSON, AL
PRICE, WA
WONG, PC
WEXLER, RR
TIMMERMANS, PBMWM
[J]. MEDICINAL RESEARCH REVIEWS, 1992, 12 (02) : 149 - 191
[9] SIGNIFICANCE OF THE VASCULAR RENIN-ANGIOTENSIN PATHWAY
DZAU, VJ
[J]. HYPERTENSION, 1986, 8 (07) : 553 - 559
[10] CHARACTERIZATION OF BINDING-SITES FOR THE ANGIOTENSIN-II ANTAGONIST I-125-[SARC1,ILE8]-ANGIOTENSIN-II ON MURINE NEURO-BLASTOMA N1E-115-CELLS
FLUHARTY, SJ
REAGAN, LP
[J]. JOURNAL OF NEUROCHEMISTRY, 1989, 52 (05) : 1393 - 1400