HALOTHANE BIOTRANSFORMATION IN ANESTHETISTS

被引:12
作者
DUVALDESTIN, P
MAZZE, RI
HAZEBROUCK, J
NIVOCHE, Y
COHEN, SE
DESMONTS, JM
机构
[1] UNIV PARIS 7, HOP BICHAT DEPT ANESTHESIOL, F-75221 PARIS 05, FRANCE
[2] STANFORD UNIV, MED CTR, SCH MED, DEPT ANESTHESIA, STANFORD, CA 94305 USA
[3] VET ADM HOSP, PALO ALTO, CA 94304 USA
关键词
D O I
10.1097/00000542-197907000-00009
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Serum bromide levels were measured in 115 anesthetists by use of X-ray fluorescence spectrometry. Bromide levels peaked at 184 .+-. 21 .mu.M in anesthetists regularly exposed to halothane (n = 20), at 58 .+-. 4 .mu.M in anesthetists sporadically exposed to halothane (n = 71) and at 46 .+-. 3 .mu.M in nonexposed anesthetists (n = 24). Kinetic studies were carried out in 5 other anesthetists after 10 days of exposure to halothane. The average daily halothane concentration was 19.2 .+-. 3.2 ppm; duration of exposure was 3.8 .+-. 0.2 h/day. Mean serum bromide level increased frm from 40 .+-. 4 .mu.M before exposure to 220 .+-. 36 .mu.M on the last day of exposure. Serum bromide half-life was 14 .+-. 1.7 days. The study demonstrates that anesthetists debrominate halothane in a dose-related fashion. Serum bromide levels achieved, however, were far below those reported to result in clinical bromism.
引用
收藏
页码:41 / 46
页数:6
相关论文
共 22 条
  • [11] A RAPID SCREENING TEST FOR BROMISM
    GAFF, G
    RAND, MJ
    DIAMOND, J
    [J]. MEDICAL JOURNAL OF AUSTRALIA, 1969, 1 (19) : 967 - &
  • [12] GOODWIN JF, 1971, CLIN CHEM, V17, P544
  • [13] INCREASED SERUM BROMIDE CONCENTRATION AFTER HALOTHANE ANESTHESIA IN MAN
    JOHNSTONE, RE
    KENNELL, EM
    BEHAR, MG
    BRUMMUND, W
    EBERSOLE, RC
    SHAW, LM
    [J]. ANESTHESIOLOGY, 1975, 42 (05) : 598 - 601
  • [14] BROMIDE CONCENTRATIONS OF ANESTHETISTS
    JOHNSTONE, RE
    ANDREWS, R
    BRUMMUND, W
    [J]. ANESTHESIOLOGY, 1975, 43 (01) : 128 - 128
  • [15] INORGANIC FLUORIDE NEPHROTOXICITY - PROLONGED ENFLURANE AND HALOTHANE ANESTHESIA IN VOLUNTEERS
    MAZZE, RI
    CALVERLEY, RK
    SMITH, NT
    [J]. ANESTHESIOLOGY, 1977, 46 (04) : 265 - 271
  • [16] SEPARATION OF IODINATED TYROSINES AND THYROXINE FROM SERUM
    PITTRIVERS, R
    SACKS, BI
    [J]. BIOCHEMICAL JOURNAL, 1962, 82 (01) : 111 - &
  • [17] INFLUENCE OF DIETARY CHLORIDE ON BROMIDE EXCRETION IN RAT
    RAUWS, AG
    VANLOGTEN, MJ
    [J]. TOXICOLOGY, 1975, 3 (01) : 29 - 32
  • [18] HALOTHANE BIOTRANSFORMATION IN MAN - A QUANTITATIVE STUDY
    REHDER, K
    FORBES, J
    ALTER, H
    HESSLER, O
    STIER, A
    [J]. ANESTHESIOLOGY, 1967, 28 (04) : 711 - &
  • [19] STIER A, 1964, ANESTH ANALG, V43, P723
  • [20] ELEVATION OF PLASMA BROMIDE LEVELS IN PATIENTS FOLLOWING HALOTHANE ANESTHESIA - TIME CORRELATION WITH TOTAL HALOTHANE DOSAGE
    TINKER, JH
    GANDOLFI, AJ
    VANDYKE, RA
    [J]. ANESTHESIOLOGY, 1976, 44 (03) : 194 - 196