SYNTHESIS OF STABLE ISOTOPE-LABELED ANALOGS OF THE CYSTEINE AND N-ACETYLCYSTEINE CONJUGATES OF TETRACHLOROETHYLENE

被引：3

作者：

BARTELS, MJ ^{[1
]}

MINER, VW ^{[1
]}

机构：

[1] DOW CHEM CO USA,ANALYT CHEM INSTRUMENTAL ANAL,MIDLAND,MI 48674

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1990年 / 28卷 / 02期

关键词：

D O I：

10.1002/jlcr.2580280212

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Stable isotope‐labelled analogs of the cysteine and N‐acetylcysteine conjugates of tetrachloroethylene have been prepared. S‐(1,2,2‐Trichlorovinyl)‐DL‐cysteine‐3,3‐2H2 was synthesized in a rapid, one‐step procedure from tetrachloroethylene and DL‐cysteine‐3,3‐2H2. Unlabelled S‐(1,2,2‐trichlorovinyl)‐L‐cysteine was prepared in a similar fashion. The corresponding 13C‐N‐acetyl‐S‐(1,2,2‐trichlorovinyl)cysteine compounds were then prepared via acetylation of the deuterated and unlabelled cysteine conjugates with 13C‐acetyl chloride. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：209 / 214

页数：6

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