SOLID-PHASE SYNTHESIS OF A MODEL NUCLEOPEPTIDE WITH A PHOSPHODIESTER BOND BETWEEN THE 5' END OF A TRINUCLEOTIDE AND A SERINE RESIDUE

被引：19

作者：

ROBLES, J

PEDROSO, E

GRANDAS, A

机构：

[1] Departament de Química Orgànica, Facultat de Química, Universitat de Barcelona, 08028 Barcelona

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 34期

关键词：

NUCLEOPEPTIDES; SOLID PHASE; PHOSPHITE TRIESTER; SERINE-NUCLEOSIDE PHOSPHATE DIESTER BOND;

D O I：

10.1016/S0040-4039(00)92178-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The model nucleopeptide Boc-Ser(pTCT)-NHcHex has been assembled on a polystyrene solid support using the phosphite triester approach. Fmoc and cyanoethyl groups have been used to protect the exocyclic amine of cytosine and phosphate groups respectively. Final deprotection has been carried out by treatment with methanolic potassium carbonate.

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收藏

页码：4389 / 4392

页数：4

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