CHANGES IN IMMEDIATE VISUAL MEMORY PREDICT COGNITIVE IMPAIRMENT

被引：68

作者：

ZONDERMAN, AB ^{[1
]}

GIAMBRA, LM ^{[1
]}

ARENBERG, D ^{[1
]}

RESNICK, SM ^{[1
]}

COSTA, PT ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,BALTIMORE,MD

来源：

ARCHIVES OF CLINICAL NEUROPSYCHOLOGY | 1995年 / 10卷 / 02期

关键词：

D O I：

10.1016/0887-6177(94)00040-9

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Six-year changes in immediate visual memory performance assessed by the Benton Visual Retention (BVR) test predicted Alzheimer's disease (AD) prior to its onset. Subjects of this study were 371 community-dwelling adult participants in the Baltimore Longitudinal Study of Aging, seven of whom received probable or definite AD diagnoses using DSM-III-R and NINCDS-ADRDA criteria. Subjects with diagnoses of AD had larger changes in immediate memory performance over the 6-year interval prior to the estimated onset of their disease than subjects without AD. Six-year longitudinal change as well as level in immediate visual memory performance also predicted subsequent cognitive performance 6-15 and 16-22 years later even after adjusting for the influences of age general-ability and initial immediate memory. These results provide evidence that change and level in immediate visual memory performance has long-term prognostic significance over as many as 16-22 years. These results further suggest that change in recent memory performance, an important component in AD diagnoses, may be an important precursor of the development of the disease.

引用

页码：111 / 123

页数：13