POSITIVE SELECTION IN AUTOIMMUNITY - ABNORMAL IMMUNE-RESPONSES TO A BACTERIAL DNAJ ANTIGENIC DETERMINANT IN PATIENTS WITH EARLY RHEUMATOID-ARTHRITIS

被引：148

作者：

ALBANI, S

KEYSTONE, E

NELSON, JL

OLLIER, WER

LACAVA, A

MONTEMAYOR, AC

WEBER, DA

MONTECUCCO, C

MARTINI, A

CARSON, DA

机构：

[1] UNIV CALIF SAN DIEGO, SAM & ROSE STEIN INST RES AGING, LA JOLLA, CA 92093 USA

[2] UNIV TORONTO, WELLESLEY HOSP, RHEUMAT DIS UNIT, TORONTO, ON M4Y 1J3, CANADA

[3] FRED HUTCHINSON CANC RES CTR, SEATTLE, WA 98104 USA

[4] UNIV MANCHESTER, ARC, EPIDEMIOL RES UNIT, MANCHESTER M13 9PT, LANCS, ENGLAND

[5] UNIV PAVIA, POLICLIN SAN MATTEO, DEPT PEDIAT, I-27100 PAVIA, ITALY

来源：

NATURE MEDICINE | 1995年 / 1卷 / 05期

关键词：

D O I：

10.1038/nm0595-448

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel 'multistep molecular mimicry' mechanism for induction of rheumatoid arthritis (RA) by bacterial antigens that activate T lymphocytes previously 'educated' by peptides derived from a class of human histocompatibility antigens is reported here. These antigens have the amino acid sequence QKRAA, which is also present on the Escherichia coli heat-shock protein dnaj. Synovial fluid cells of early RA patients have strong immune responses to the bacterial antigen, but cells from normal subjects or controls with other autoimmune diseases do not. The activated T cells may cross-react with autologous dnaj heat-shock proteins that are expressed at synovial sites of inflammation. Our findings may have direct relevance to new strategies for the immune therapy of RA.

引用

页码：448 / 452

页数：5