THE HUMAN RD PROTEIN IS CLOSELY RELATED TO NUCLEAR RNA-BINDING PROTEINS AND HAS BEEN HIGHLY CONSERVED

被引：30

作者：

SUROWY, CS

HOGANSON, G

GOSINK, J

STRUNK, K

SPRITZ, RA

机构：

[1] Department of Medical Genetics, University of Wisconsin, Madison

来源：

GENE | 1990年 / 90卷 / 02期

关键词：

gene evolution; nucleotide sequence; Recombinant DNA; ribonucleoprotein-encoding genes; RNP consensus domain;

D O I：

10.1016/0378-1119(90)90194-V

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have isolated cDNA clones encoding the human RD protein, which is closely related to several known nuclear RNA-binding proteins. The RD protein contains a 60-amino acid (aa) tract almost entirely of alternating basic and acidic aa, (RD)n, primarily arginine (Arg; R) and aspartic acid (Asp; D). The protein also contains an 'RNP sequence domain'. Arg-rich tracts and the RNP sequence domain are both features of nuclear RNA-binding proteins. However, we have been unable to detect RNA-binding by the human RD protein. The very strong evolutionary conservation of the mammalian RD protein as sequence suggests that it plays an important role in the cell. © 1990.

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页码：299 / 302

页数：4

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