FACILE SYNTHESIS OF ALPHA-TRIFLUOROMETHYLATED ALCOHOLS FROM TRIFLUOROACETALDEHYDE ETHYL HEMIACETAL

被引：39

作者：

KUBOTA, T

IIJIMA, M

TANAKA, T

机构：

[1] Department of Industrial Chemistry, Ibaraki University, Hitachi, Ibaraki, 316, Nakanarusawa-machi

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 10期

关键词：

TRIFLUOROACETALDEHYDE ETHYL HEMIACETAL; LEWIS ACID; TRIMETHYLSILYLATED NUCLEOPHILES; CARBON-CARBON BOND FORMATION; ALPHA-TRIFLUOROMETHYLATED ALCOHOL;

D O I：

10.1016/S0040-4039(00)91620-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Trifluoroacetaldehyde ethyl hemiacetal reacted with nucleophilic organosilanes such as cyanotrimethylsilane, allyltrimethylsilane, or enol trimethylsilyl ethers in the presence of Lewis acid to afford a series of alpha-trifluoromethylated alcohols in high yield.

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页码：1351 / 1354

页数：4

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