SYNTHESIS OF (2R,3R)-, (2S,3S)-, (2R,3S)- AND (2S,3R)-IMIDAZOLE GLYCEROL PHOSPHATES (IGP) - SUBSTRATES FOR IGP-DEHYDRATASE (IGPD)

被引：17

作者：

SAIKA, H

FRUH, T

IWASAKI, G

KOIZUMI, S

MORI, I

HAYAKAWA, K

机构：

[1] CIBA GEIGY JAPAN LTD,INT RES LABS,DEPT CHEM,TAKARAZUKA,HYOGO 665,JAPAN

[2] CIBA GEIGY JAPAN LTD,INT RES LABS,BIOORGAN RES DEPT,TAKARAZUKA,HYOGO 665,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(01)81031-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

D-erythro-(2R,3S)-Imidazole glycerol phosphate (IGP) and its stereoisomers [(2S,3R), (2R,3R), (2S,3S)] have been synthesized via the Evans aldol reaction. The stereochemical assignments of these isomers and their IGPD-substrate activities were studied.

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页码：2129 / 2134

页数：6

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