MYC PROTEIN - PARTNERS AND ANTAGONISTS

被引：31

作者：

VASTRIK, I ^{[1
]}

MAKELA, TP ^{[1
]}

KOSKINEN, PJ ^{[1
]}

KLEFSTROM, J ^{[1
]}

ALITALO, K ^{[1
]}

机构：

[1] UNIV HELSINKI,DEPT PATHOL,MOLEC CANC BIOL LAB,POB 21 HAARTMANINKATU 3,SF-00100 HELSINKI 10,FINLAND

来源：

CRITICAL REVIEWS IN ONCOGENESIS | 1994年 / 5卷 / 01期

关键词：

TRANSFORMATION; TRANSCRIPTION FACTOR; MAX; MAD; MXI1;

D O I：

10.1615/CritRevOncog.v5.i1.30

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One of the first oncogenes identified from human tumors was c-myc, which is frequently activated in Burkitt's lymphomas due to chromosomal translocations. Subsequently, members of the myc oncogene family were found to be amplified in neuroblastoma and small-cell lung cancer. In normal cells, Myc activity has been shown to be both necessary and sufficient for resting cells to enter the cell cycle. Interestingly, it appears that Myc not only drives the cell cycle, but also induces cell death by apoptosis in certain situations. Myc contains a transcriptional activation domain and a basic helix-loop-helix-leucine zipper DNA-binding and dimerization domain. As a heterodimer with a structurally related protein, Max, Myc can bind DNA in a sequence-specific manner. These results suggest that the Myc/Max heterodimer functions as a transcriptional activator of genes that are critical for the regulation of cell growth.

引用

页码：59 / 68

页数：10

共 76 条

[11] CASEIN KINASE-II INHIBITS THE DNA-BINDING ACTIVITY OF MAX HOMODIMERS BUT NOT MYC MAX HETERODIMERS [J].