SPECIES-DIFFERENCES IN THE METABOLISM OF FEPRAZONE, AN ANTI-INFLAMMATORY DRUG

被引：4

作者：

GAETANI, M

YAMAGUCHI, H

VIDI, A

HASHIMOTO, Y

DONETTI, A

机构：

[1] IST ANGELI SPA, RES LAB, MILAN, ITALY

[2] TEIJIN INST BIO MED RES, TOKYO, JAPAN

来源：

PHARMACOLOGICAL RESEARCH COMMUNICATIONS | 1979年 / 11卷 / 08期

关键词：

D O I：

10.1016/S0031-6989(79)80061-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The metabolism of feprazone [1,2-diphenyl-3,5-dioxo-4-prenyl-pyrazolidine], an antiinflammatory drug, in rat, dog and man was studied using TLC, HPLC [high performance liquid chromatography], GC-MS [gas chromatography-mass spectroscopy] techniques in conjunction with stable isotope labeling. Metabolites (8) were identified and some were detected commonly in rat and dog. Feprazone-(C)-.beta. glucuronide found in man as a main urinary metabolite was not present in rat and dog.

引用

页码：719 / 730

页数：12

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