MAJOR GROOVE DNA RECOGNITION BY BETA-SHEETS - THE RIBBON-HELIX-HELIX FAMILY OF GENE REGULATORY PROTEINS

被引：73

作者：

RAUMANN, BE

BROWN, BM

SAUER, RT

机构：

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1994年 / 4卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-440X(94)90057-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Co-crystal structures of the MetJ and Arc repressors reveal that both proteins use a two-stranded antiparallel beta-sheet for recognition of bases in the major groove of operator DNA and make conserved contacts with the DNA backbone. Important differences between the two proteins include the surfaces used for cooperative dimer-dimer contacts and the symmetry and positions of base contacts made by beta-sheet side chains.

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页码：36 / 43

页数：8

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