ANOMALOUS PH-DEPENDENCE OF KCAT-KM KM IN ENZYME REACTIONS - RATE CONSTANTS FOR ASSOCIATION OF CHYMOTRYPSIN WITH SUBSTRATES

被引：48

作者：

RENARD, M ^{[1
]}

FERSHT, AR ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,POSTGRAD MED SCH,MRC,LAB MOLEC BIOL,CAMBRIDGE CB2 2QH,ENGLAND

来源：

BIOCHEMISTRY | 1973年 / 12卷 / 23期

关键词：

D O I：

10.1021/bi00747a026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：4713 / 4718

页数：6

共 17 条

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[3] CORRELATION OF PH (PD) DEPENDENCE + STEPWISE MECHANISM OF ALPHA-CHYMOTRYPSIN-CATALYZED REACTIONS
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CLEMENT, GE
HECK, HD
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[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (18) : 3680 - &
[4] THE EFFECT OF PH ON THE AFFINITIES OF ENZYMES FOR SUBSTRATES AND INHIBITORS
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[J]. BIOCHEMICAL JOURNAL, 1953, 55 (01) : 161 - 170
[5] EIGEN M, 1963, ADVAN ENZYMOL, V25, P13
[6] MECHANISM OF CHYMOTRYPSIN - STRUCTURE, REACTIVITY, AND NONPRODUCTIVE BINDING RELATIONSHIPS
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[J]. BIOCHEMISTRY, 1973, 12 (06) : 1067 - 1074
[7] DEMONSTRATION OF ACYL-ENZYME MECHANISM FOR HYDROLYSIS OF PEPTIDES AND ANILIDES BY CHYMOTRYPSIN
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FERSHT, AR
[J]. BIOCHEMISTRY, 1973, 12 (11) : 2025 - 2034
[8] MECHANISM OF ALPHA-CHYMOTRYPSIN-CATALYZED HYDROLYSIS OF SPECIFIC AMIDE SUBSTRATES
FERSHT, AR
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1972, 94 (01) : 293 - &
[9] MECHANISM OF ALPHA-CHYMOTRYPSIN-CATALYZED HYDROLYSIS OF AMIDES - PH DEPENDENCE OF KC AND KM - KINETIC DETECTION OF AN INTERMEDIATE
FERSHT, AR
REQUENA, Y
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1971, 93 (25) : 7079 - +
[10] CONFORMATIONAL EQUILIBRIA IN ALPHA-CHYMOTRYPSIN AND DELTA-CHYMOTRYPSIN - ENERGETICS AND IMPORTANCE OF SALT BRIDGE
FERSHT, AR
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1972, 64 (02) : 497 - &

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