NEW CYCLOBUTYL ANALOGS OF NUCLEOSIDES .2. SYNTHESIS AND ANTIVIRAL EVALUATION OF 2-AMINO-7-[3,3-BIS(HYDROXYMETHYL)CYCLOBUT-1-YL]-3H,7H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE AND OF CYCLOBUTYL ANALOGS OF THE PYRIMIDINE NUCLEOSIDES

被引：4

作者：

BOUMCHITA, H

LEGRAVEREND, M

ZERIAL, A

LEMAITRE, M

HUEL, C

BISAGNI, E

机构：

[1] INST CURIE, CNRS,URA 1387,INSERM,U219,BIOL SECT,BAT 110-112, CTR UNIV, F-91405 ORSAY, FRANCE

[2] RHONE POULENC SANTE, F-94403 VITRY, FRANCE

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 26卷 / 06期

关键词：

OXETANOCIN ANALOGS; CARBOCYCLIC NUCLEOSIDES; ANTIVIRAL ACTIVITY;

D O I：

10.1016/0223-5234(91)90196-T

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and antiviral evaluation of a series of 3,3-dihydroxymethyl cyclobutane nucleoside analogs related to the natural anti-HIV nucleoside, oxetanocin A are reported. The different purine and pyrimidine nucleoside analogs described in this paper have been obtained from 1-amino-3,3-dibenzyloxymethylcyclobutane. The compounds were tested against HSV-1, HCMV and HIV-1 in cell cultures, but none of them exhibited activity against these viruses. These results suggest the crucial role of the position of both hydroxymethyl groups in oxetanocin A and oxetanocin G for antiviral activity.

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页码：613 / 617

页数：5

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