SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF COMBINED THROMBOXANE RECEPTOR ANTAGONIST THROMBOXANE SYNTHASE INHIBITORS - PYRIDINE-CONTAINING AMINO-PROSTANOIDS

被引：11

作者：

CAMPBELL, IB ^{[1
]}

COLLINGTON, EW ^{[1
]}

FINCH, H ^{[1
]}

HAYES, R ^{[1
]}

LUMLEY, P ^{[1
]}

MILLS, K ^{[1
]}

ROBERTSON, GM ^{[1
]}

WHARTON, K ^{[1
]}

WATTS, IS ^{[1
]}

机构：

[1] GLAXO GRP RES LTD,DEPT PERIPHERAL PHARMACOL,WARE SG12 ODP,HERTS,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)81050-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Incorporation of a pyridine moiety into amino-prostanoids, previously shown to be thromboxane receptor antagonists, has provided a series of compounds which also show potent thromboxane synthase inhibitory activity. GR 83783, an (n)propyl-substituted pyridine demonstrates these properties both in vitro and in vivo.

引用

页码：695 / 698

页数：4

共 16 条

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CAMPBELL, IB
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