SYNTHESIS AND BIOLOGICAL-ACTIVITY OF NOVEL 3-(2-PROPENYL)-CEPHALOSPORINS .1.

被引：4

作者：

KIM, WJ

KO, KY

KIM, H

OH, J

机构：

[1] Research Institute of Chemical Technology, Daejeon, P.O. Box 9, Daedeog-Danji

[2] Ajou University, Suwon

[3] Dongkuk University, Seoul

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 10期

关键词：

D O I：

10.7164/antibiotics.44.1073

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The synthesis, antibacterial activity and oral absorption of novel cephalosporins (3a approximately 3d) having a 2-propenyl group at the C-3 position are described. Diphenylmethyl 7-amino-3-(2-propenyl)-3-cephem-4-carboxylate HCl (4) prepared from 7-aminocephalosporanic acid in 12 steps was acylated with various acid moieties to give cephems 3a approximately 3d. The cephems 3a approximately showed similar antibacterial activities as cefixime. However, these cephems were not well absorbed orally.

引用

页码：1073 / 1082

页数：10

共 15 条

[11] CHEMISTRY OF CEPHALOSPORIN ANTIBIOTICS .13. DESACETOXYCEPHALOSPORINS . SYNTHESIS OF CEPHALEXIN AND SOME ANALOGS [J].