REGULATION OF CA2+ CONCENTRATION BP 2ND MESSENGERS IN NEWT OLFACTORY RECEPTOR CELL

被引：22

作者：

NAKAMURA, T

TSURU, K

MIYAMOTO, S

机构：

[1] Department of Applied Physics and Chemistry, The University of Electro-Communications, Chofu, Tokyo, 182

来源：

NEUROSCIENCE LETTERS | 1994年 / 171卷 / 1-2期

关键词：

OLFACTORY TRANSDUCTION; CYCLIC AMP; IP3; INTRACELLULAR CA2+; WHOLE CELL CLAMP; FURA-2;

D O I：

10.1016/0304-3940(94)90638-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role of IP3 in olfactory transduction is controversial. This issue was addressed by measuring intracellular Ca2+ concentration under voltage clamp in newt olfactory receptor cells. Odorant stimulation and dialysis of cells with cyclic AMP (cAMP) caused an increase in intracellular Ca2+ concentration that originated in the cilia, as expected from previous works. However, dialysis with IP3 caused a slower rise in Ca2+ concentration that originated in the cell body. Our results suggest that IP3 influences transduction by regulating the intracellular Ca2+ concentration, rather than by carrying the transduction current.

引用

页码：197 / 200

页数：4

共 22 条

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