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CONTRACTILE, METABOLIC AND ELECTROPHYSIOLOGIC EFFECTS OF ETHANOL IN THE ISOLATED RAT-HEART
被引:22
作者
:
SCHULMAN, SP
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV, SCH MED, DEPT MED, DIV CARDIOL, BALTIMORE, MD 21205 USA
SCHULMAN, SP
LAKATTA, EG
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV, SCH MED, DEPT MED, DIV CARDIOL, BALTIMORE, MD 21205 USA
LAKATTA, EG
WEISS, RG
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV, SCH MED, DEPT MED, DIV CARDIOL, BALTIMORE, MD 21205 USA
WEISS, RG
WOLFF, MR
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV, SCH MED, DEPT MED, DIV CARDIOL, BALTIMORE, MD 21205 USA
WOLFF, MR
HANO, O
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV, SCH MED, DEPT MED, DIV CARDIOL, BALTIMORE, MD 21205 USA
HANO, O
GERSTENBLITH, G
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV, SCH MED, DEPT MED, DIV CARDIOL, BALTIMORE, MD 21205 USA
GERSTENBLITH, G
机构
:
[1]
JOHNS HOPKINS UNIV, SCH MED, DEPT MED, DIV CARDIOL, BALTIMORE, MD 21205 USA
[2]
NIA, GERONTOL RES CTR, BALTIMORE, MD 21224 USA
来源
:
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
|
1991年
/ 23卷
/ 04期
关键词
:
ETHANOL;
EXCITATION CONTRACTION COUPLING;
HIGH ENERGY PHOSPHATES;
CALCIUM;
LEFT VENTRICULAR FUNCTION;
D O I
:
10.1016/0022-2828(91)90166-J
中图分类号
:
R5 [内科学];
学科分类号
:
1002 ;
100201 ;
摘要
:
The metabolic, functional and electrical effects of ethanol were studied in the isolated isovolumic rat heart retrogradely perfused at constant flow using phosphorus-31 nuclear magnetic resonance spectroscopy and surface electrogram recordings. Ethanol (0.75 to 6.0 vol%; 128 to 1024 mm) caused a concentration-dependent decline in developed pressure without a change in adenosine triphosphate, phosphocreatine, inorganic phosphate or pH. Ethanol (6%) caused abolition of electrical activity. The functional decline could be rapidly and completely reversed by perfusing with ethanol-free solution and, significantly although not completely, reversed by increasing perfusate calcium to 4 mm. Furthermore, ethanol shifted the perfusate calcium-tetanic pressure relationship in the presence of ryanodine (1 μm) downwards and to the right. The results suggest ethanol's acute effects in this model are not mediated by changes in energy metabolism or cellular pH, but rather by sarcolemmal effects and by a decrease in both myofilament calcium sensitivity and maximal force generating ability. © 1991.
引用
收藏
页码:417 / 426
页数:10
相关论文
共 38 条
[31]
EFFECTS OF ETHANOL ON CALCIUM-TRANSPORT BY MICROSOMES PHOSPHORYLATED BY CYCLIC AMP-DEPENDENT PROTEIN-KINASE
RETIG, JN
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0
引用数:
0
h-index:
0
机构:
CUNY,MT SINAI SCH MED,DEPT MED,DIV CARDIOL,NEW YORK,NY 10029
RETIG, JN
KIRCHBERGER, MA
论文数:
0
引用数:
0
h-index:
0
机构:
CUNY,MT SINAI SCH MED,DEPT MED,DIV CARDIOL,NEW YORK,NY 10029
KIRCHBERGER, MA
RUBIN, E
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0
引用数:
0
h-index:
0
机构:
CUNY,MT SINAI SCH MED,DEPT MED,DIV CARDIOL,NEW YORK,NY 10029
RUBIN, E
KATZ, AM
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0
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CUNY,MT SINAI SCH MED,DEPT MED,DIV CARDIOL,NEW YORK,NY 10029
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RYANODINE MODIFICATION OF CARDIAC-MUSCLE RESPONSES TO POTASSIUM-FREE SOLUTIONS - EVIDENCE FOR INHIBITION OF SARCOPLASMIC-RETICULUM CALCIUM RELEASE
SUTKO, JL
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UNIV TEXAS,HLTH SCI CTR,DEPT INTERNAL MED,DIV CARDIOL,DALLAS,TX 75235
SUTKO, JL
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SWARTZ, MH
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h-index:
0
机构:
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED & PATHOL,DIV CARDIOL,FIFTH AVE &100TH ST,NEW YORK,NY 10029
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED & PATHOL,DIV CARDIOL,FIFTH AVE &100TH ST,NEW YORK,NY 10029
SWARTZ, MH
REPKE, DI
论文数:
0
引用数:
0
h-index:
0
机构:
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED & PATHOL,DIV CARDIOL,FIFTH AVE &100TH ST,NEW YORK,NY 10029
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED & PATHOL,DIV CARDIOL,FIFTH AVE &100TH ST,NEW YORK,NY 10029
REPKE, DI
KATZ, AM
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0
引用数:
0
h-index:
0
机构:
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED & PATHOL,DIV CARDIOL,FIFTH AVE &100TH ST,NEW YORK,NY 10029
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED & PATHOL,DIV CARDIOL,FIFTH AVE &100TH ST,NEW YORK,NY 10029
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CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED & PATHOL,DIV CARDIOL,FIFTH AVE &100TH ST,NEW YORK,NY 10029
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TAKEDA, R
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0
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0
TAKEDA, R
MOMOSE, Y
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MOMOSE, Y
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NAKANISHI, S
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ETHANOL INHIBITS ELECTRICALLY-INDUCED CALCIUM TRANSIENTS IN ISOLATED RAT CARDIAC MYOCYTES
THOMAS, AP
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0
引用数:
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0
THOMAS, AP
SASS, EJ
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SASS, EJ
TUNKIRCHMANN, TT
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TUNKIRCHMANN, TT
RUBIN, E
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RUBIN, E
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EFFECT OF ETHANOL AND ACETALDEHYDE ON (NA+ + K+)-ACTIVATED ADENOSINE-TRIPHOSPHATASE ACTIVITY OF CARDIAC PLASMA-MEMBRANES
WILLIAMS, JW
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0
引用数:
0
h-index:
0
机构:
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED,DIV CARDIOL,NEW YORK,NY
WILLIAMS, JW
TADA, M
论文数:
0
引用数:
0
h-index:
0
机构:
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED,DIV CARDIOL,NEW YORK,NY
TADA, M
KATZ, AM
论文数:
0
引用数:
0
h-index:
0
机构:
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED,DIV CARDIOL,NEW YORK,NY
KATZ, AM
RUBIN, E
论文数:
0
引用数:
0
h-index:
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机构:
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED,DIV CARDIOL,NEW YORK,NY
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DEPRESSION OF CARDIAC PERFORMANCE BY ETHANOL UNMASKED DURING AUTONOMIC BLOCKADE
WONG, M
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0
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WADSWORTH HOSP CTR,CARDIOL SECT,LOS ANGELES,CA 90073
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←
1
2
3
4
→
共 38 条
[31]
EFFECTS OF ETHANOL ON CALCIUM-TRANSPORT BY MICROSOMES PHOSPHORYLATED BY CYCLIC AMP-DEPENDENT PROTEIN-KINASE
RETIG, JN
论文数:
0
引用数:
0
h-index:
0
机构:
CUNY,MT SINAI SCH MED,DEPT MED,DIV CARDIOL,NEW YORK,NY 10029
RETIG, JN
KIRCHBERGER, MA
论文数:
0
引用数:
0
h-index:
0
机构:
CUNY,MT SINAI SCH MED,DEPT MED,DIV CARDIOL,NEW YORK,NY 10029
KIRCHBERGER, MA
RUBIN, E
论文数:
0
引用数:
0
h-index:
0
机构:
CUNY,MT SINAI SCH MED,DEPT MED,DIV CARDIOL,NEW YORK,NY 10029
RUBIN, E
KATZ, AM
论文数:
0
引用数:
0
h-index:
0
机构:
CUNY,MT SINAI SCH MED,DEPT MED,DIV CARDIOL,NEW YORK,NY 10029
KATZ, AM
[J].
BIOCHEMICAL PHARMACOLOGY,
1977,
26
(05)
: 393
-
396
[32]
RUBIN E, 1979, NEW ENGL J MED, V301, P28
[33]
RYANODINE MODIFICATION OF CARDIAC-MUSCLE RESPONSES TO POTASSIUM-FREE SOLUTIONS - EVIDENCE FOR INHIBITION OF SARCOPLASMIC-RETICULUM CALCIUM RELEASE
SUTKO, JL
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TEXAS,HLTH SCI CTR,DEPT INTERNAL MED,DIV CARDIOL,DALLAS,TX 75235
SUTKO, JL
KENYON, JL
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV TEXAS,HLTH SCI CTR,DEPT INTERNAL MED,DIV CARDIOL,DALLAS,TX 75235
KENYON, JL
[J].
JOURNAL OF GENERAL PHYSIOLOGY,
1983,
82
(03)
: 385
-
404
[34]
EFFECTS OF ETHANOL ON CALCIUM-BINDING AND CALCIUM-UPTAKE BY CARDIAC-MICROSOMES
SWARTZ, MH
论文数:
0
引用数:
0
h-index:
0
机构:
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED & PATHOL,DIV CARDIOL,FIFTH AVE &100TH ST,NEW YORK,NY 10029
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED & PATHOL,DIV CARDIOL,FIFTH AVE &100TH ST,NEW YORK,NY 10029
SWARTZ, MH
REPKE, DI
论文数:
0
引用数:
0
h-index:
0
机构:
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED & PATHOL,DIV CARDIOL,FIFTH AVE &100TH ST,NEW YORK,NY 10029
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED & PATHOL,DIV CARDIOL,FIFTH AVE &100TH ST,NEW YORK,NY 10029
REPKE, DI
KATZ, AM
论文数:
0
引用数:
0
h-index:
0
机构:
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED & PATHOL,DIV CARDIOL,FIFTH AVE &100TH ST,NEW YORK,NY 10029
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED & PATHOL,DIV CARDIOL,FIFTH AVE &100TH ST,NEW YORK,NY 10029
KATZ, AM
RUBIN, E
论文数:
0
引用数:
0
h-index:
0
机构:
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED & PATHOL,DIV CARDIOL,FIFTH AVE &100TH ST,NEW YORK,NY 10029
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED & PATHOL,DIV CARDIOL,FIFTH AVE &100TH ST,NEW YORK,NY 10029
RUBIN, E
[J].
BIOCHEMICAL PHARMACOLOGY,
1974,
23
(17)
: 2369
-
2376
[35]
EFFECTS OF ETHANOL ON CALCIUM AND POTASSIUM CURRENTS IN SINGLE BULLFROG ATRIAL CELLS
TAKEDA, R
论文数:
0
引用数:
0
h-index:
0
TAKEDA, R
MOMOSE, Y
论文数:
0
引用数:
0
h-index:
0
MOMOSE, Y
NAKANISHI, S
论文数:
0
引用数:
0
h-index:
0
NAKANISHI, S
[J].
JAPANESE JOURNAL OF PHARMACOLOGY,
1984,
36
(03)
: 422
-
424
[36]
ETHANOL INHIBITS ELECTRICALLY-INDUCED CALCIUM TRANSIENTS IN ISOLATED RAT CARDIAC MYOCYTES
THOMAS, AP
论文数:
0
引用数:
0
h-index:
0
THOMAS, AP
SASS, EJ
论文数:
0
引用数:
0
h-index:
0
SASS, EJ
TUNKIRCHMANN, TT
论文数:
0
引用数:
0
h-index:
0
TUNKIRCHMANN, TT
RUBIN, E
论文数:
0
引用数:
0
h-index:
0
RUBIN, E
[J].
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,
1989,
21
(06)
: 555
-
565
[37]
EFFECT OF ETHANOL AND ACETALDEHYDE ON (NA+ + K+)-ACTIVATED ADENOSINE-TRIPHOSPHATASE ACTIVITY OF CARDIAC PLASMA-MEMBRANES
WILLIAMS, JW
论文数:
0
引用数:
0
h-index:
0
机构:
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED,DIV CARDIOL,NEW YORK,NY
WILLIAMS, JW
TADA, M
论文数:
0
引用数:
0
h-index:
0
机构:
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED,DIV CARDIOL,NEW YORK,NY
TADA, M
KATZ, AM
论文数:
0
引用数:
0
h-index:
0
机构:
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED,DIV CARDIOL,NEW YORK,NY
KATZ, AM
RUBIN, E
论文数:
0
引用数:
0
h-index:
0
机构:
CITY UNIV NEW YORK,MT SINAI SCH MED,DEPT MED,DIV CARDIOL,NEW YORK,NY
RUBIN, E
[J].
BIOCHEMICAL PHARMACOLOGY,
1975,
24
(01)
: 27
-
32
[38]
DEPRESSION OF CARDIAC PERFORMANCE BY ETHANOL UNMASKED DURING AUTONOMIC BLOCKADE
WONG, M
论文数:
0
引用数:
0
h-index:
0
机构:
WADSWORTH HOSP CTR,CARDIOL SECT,LOS ANGELES,CA 90073
WONG, M
[J].
AMERICAN HEART JOURNAL,
1973,
86
(04)
: 508
-
515
←
1
2
3
4
→