HYDRAMYCIN, A NEW ANTITUMOR ANTIBIOTIC TAXONOMY, ISOLATION, PHYSICOCHEMICAL PROPERTIES, STRUCTURE AND BIOLOGICAL-ACTIVITY

被引：7

作者：

HANADA, M

KANETA, K

NISHIYAMA, Y

HOSHINO, Y

KONISHI, M

OKI, T

机构：

[1] Bristol-Myers Squibb Research Institute, Tokyo 153, 2-9-3 Shimo-meguro, Meguro-ku

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 08期

关键词：

D O I：

10.7164/antibiotics.44.824

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new antitumor antibiotic hydramycin was isolated from the fermentation broth of Streptomyces violaceus P950-4 (ATCC 53807). It showed potent antibacterial and cytotoxic activity and increased the survival time of mice inoculated with P388 leukemia. A new structure related to the pluramycin group antibiotics was assigned by its spectroscopic experiements.

引用

页码：824 / 831

页数：8

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