CLONING AND SEQUENCING OF CDNAS ENCODING THE HUMAN HEPATOCYTE NUCLEAR FACTOR 4 INDICATE THE PRESENCE OF 2 ISOFORMS IN HUMAN LIVER

被引：74

作者：

CHARTIER, FL ^{[1
]}

BOSSU, JP ^{[1
]}

LAUDET, V ^{[1
]}

FRUCHART, JC ^{[1
]}

LAINE, B ^{[1
]}

机构：

[1] INST PASTEUR,CNRS,URA 1160,F-59045 LILLE,FRANCE

来源：

GENE | 1994年 / 147卷 / 02期

关键词：

HEPATIC TRANSCRIPTION FACTOR; HNF-4; STEROID HORMONE NUCLEAR RECEPTOR SUPERFAMILY;

D O I：

10.1016/0378-1119(94)90079-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Hepatocyte nuclear factor 4 (HNF-4) is a key transcription factor involved in the specific expression of many genes in liver and intestine. Sequences of cDNAs coding for HNF-4 have been established in rat and Drosophila melanogaster. Rat HNF-4 exhibits two isoforms which probably result from differential splicing. We have isolated HNF-4 cDNAs from an adult human cDNA library. Sequence analysis revealed that two HNF-4 isoforms are also present in human liver. The complete sequence of the longest human isoform has been established and compared to the rat HNF-4 aminoacid sequences.

引用

页码：269 / 272

页数：4

共 20 条

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