ETHANOL POTENTIATION OF 5-HT3 RECEPTOR-MEDIATED ION CURRENT IN NCB-20 NEUROBLASTOMA-CELLS

被引：91

作者：

LOVINGER, DM

机构：

[1] Unit of Synaptic Pharmacology, Section of Electrophysiology, LPPS, Rockville

来源：

NEUROSCIENCE LETTERS | 1991年 / 122卷 / 01期

关键词：

ALCOHOL; INTOXICATION; SEROTONIN; PATCH-CLAMP; NEUROBLASTOMA; ION CHANNEL;

D O I：

10.1016/0304-3940(91)90192-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of acute ethanol (EtOH) exposure on 5-HT3 receptor-mediated ion current was examined in whole-cell patch-clamp recordings from NCB-20 neuroblastoma cells. The physiologic and pharmacologic properties of 5-HT-activated ion current in NCB-20 cells indicated that it was mediated by 5-HT3 receptors. EtOH potentiated 5-HT3 receptor-mediated current in a concentration-dependent manner at concentrations (25-100 mM) which are achieved during EtOH intoxication in vivo.

引用

页码：57 / 60

页数：4

共 20 条

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