LIPASE-CATALYZED ENANTIOSELECTIVE ACYLATION OF N-PROTECTED OR UNPROTECTED 2-AMINOALKAN-1-OLS

被引：29

作者：

FERNANDEZ, S ^{[1
]}

BRIEVA, R ^{[1
]}

REBOLLEDO, F ^{[1
]}

GOTOR, V ^{[1
]}

机构：

[1] UNIV OVIEDO,DEPT QUIM ORGAN & INORGAN,E-33071 OVIEDO,SPAIN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 21期

关键词：

D O I：

10.1039/p19920002885

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Porcine pancreatic lipase (PPL) catalysed the acylation of 2-aminoalkan-1 -ols; the enantiospecificity depends on the starting amino alcohol. The catalytic activity of the enzyme was markedly improved when the benzyl carbamate derivatives were used as substrates; in general, the enzyme displayed a high enantiospecificity.

引用

页码：2885 / 2889

页数：5