CYTOKINE MESSENGER-RNA IN BRAIN-TISSUE FROM MICE THAT SHOW STRAIN-DEPENDENT DIFFERENCES IN THE SEVERITY OF LESIONS INDUCED BY SYSTEMIC INFECTION WITH CANDIDA-ALBICANS YEAST

被引:21
作者
ASHMAN, RB
BOLITHO, EM
FULURIJA, A
机构
[1] Pathology Department, University of Western Australia, Nedlands
关键词
D O I
10.1093/infdis/172.3.823
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
BALB/c and CBA/CaH mice show discrete, genetically determined patterns of tissue responses to infection with the yeast Candida albicans. By use of a semiquantitative reverse transcriptase-polymerase chain reaction, interferon (IFN)-gamma, interleukin (IL)-6, and tumor necrosis factor (TNF)-alpha were readily demonstrated in brain tissue on days 1, 3, and 5 after infection and were present in higher concentrations in CBA/CaH than in BALB/c mice. IL-2 and -4 were detected in both strains but at different time points. Both the fungus burden and the severity of the tissue damage become established before mRNA concentrations of the cytokines increase in the lesions, and the rate of clearance of the yeast is similar in both mouse strains. The data indicate that the deterministic model, which correlates Th1 and Th2 cytokines with resistance and susceptibility, respectively, is inadequate to account for the patterns of cytokine production that develop in the infected brain after sublethal challenge.
引用
收藏
页码:823 / 830
页数:8
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[1]   INDUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA IN MURINE CANDIDA-ALBICANS INFECTION [J].
ALLENDOERFER, R ;
MAGEE, DM ;
SMITH, JG ;
BONEWALD, L ;
GRAYBILL, JR .
JOURNAL OF INFECTIOUS DISEASES, 1993, 167 (05) :1168-1172
[2]  
Ashman R B, 1989, Immunol Ser, V47, P347
[4]   MURINE CANDIDIASIS - PATHOGENESIS AND HOST RESPONSES IN GENETICALLY DISTINCT INBRED MICE [J].
ASHMAN, RB ;
PAPADIMITRIOU, JM .
IMMUNOLOGY AND CELL BIOLOGY, 1987, 65 :163-171
[5]  
ASHMAN RB, 1987, J IMMUNOGENET, V14, P317
[6]   ENHANCEMENT OF MHC CLASS-II ANTIGEN EXPRESSION BY EXPOSURE TO CANDIDA-ALBICANS [J].
ASHMAN, RB .
IMMUNOLOGY LETTERS, 1991, 30 (02) :255-260
[8]   GENETIC-RESISTANCE TO CANDIDA-ALBICANS INFECTION IS CONFERRED BY CELLS DERIVED FROM THE BONE-MARROW [J].
ASHMAN, RB ;
PAPADIMITRIOU, JM .
JOURNAL OF INFECTIOUS DISEASES, 1992, 166 (04) :947-948
[10]   PATTERNS OF RESISTANCE TO CANDIDA-ALBICANS IN INBRED MOUSE STRAINS [J].
ASHMAN, RB ;
BOLITHO, EM ;
PAPADIMITRIOU, JM .
IMMUNOLOGY AND CELL BIOLOGY, 1993, 71 :221-225