EFFECTS OF LIPOXYGENASE PRODUCTS OF ARACHIDONATE METABOLISM ON PARATHYROID-HORMONE SECRETION

被引:30
作者
BOURDEAU, A [1 ]
MOUTAHIR, M [1 ]
SOUBERBIELLE, JC [1 ]
BONNET, P [1 ]
HERVIAUX, P [1 ]
SACHS, C [1 ]
LIEBERHERR, M [1 ]
机构
[1] UNIV PARIS 05, HOP NECKER ENFANTS MALAD, DEPT PHYSIOL, PARIS, FRANCE
关键词
D O I
10.1210/en.135.3.1109
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
High extracellular Ca2+ (Ca-ec(2+)) stimulates the formation of inositol phosphates and diacylglycerol and activates phospholipase A(2) in porcine parathyroid cells. Ca-ec(2+) action is also coupled to the formation of arachidonic acid, the precursor of both the cyclooxygenase and lipoxygenase (LO) pathways. We previously reported that LO pathway products might act as second messengers and play a part in regulating PTH secretion by Ca-ec(2+). We have now investigated the effects of hydroxyeicosatetranoic acids (HETEs) on PTH secretion. Collagenase-dispersed porcine parathyroid cells were incubated in low [Ca2+] (0.5 mM, maximal stimulation) with or without HETEs for three 15-min periods. 12- and 15-HETEs inhibited PTH secretion in a dose-dependent manner from 10(-12) to 10(-9) M. Maximal inhibition was with 10(-9) M. Since 12- and 15-HETEs are the metabolic reduction products of 12- and 15-HPETEs, we also examined the effect of those precursors on PTH release. 12- and 15-hydroxyperoxyeicosatetranoic acids (HPETEs) were more potent inhibitors of PTH secretion. The threshold concentrations of both HPETEs that inhibited PTH release were lower than those for HETEs: 10(-9) M suppressed PTH secretion. This effect is comparable to that of high [Ca2+] (2 mM). This provides new evidence that products of 12-LO and 15-LO pathways are potent inhibitors of PTH secretion.
引用
收藏
页码:1109 / 1112
页数:4
相关论文
共 30 条
[21]   FUNCTIONAL EXPRESSION OF THE PARATHYROID CELL CALCIUM RECEPTOR IN XENOPUS-OOCYTES [J].
RACKE, FK ;
HAMMERLAND, LG ;
DUBYAK, GR ;
NEMETH, EF .
FEBS LETTERS, 1993, 333 (1-2) :132-136
[22]   MOBILIZATION OF MITOCHONDRIAL CA-2+ BY HYDROPEROXY-EICOSATETRAENOIC ACID [J].
RICHTER, C ;
FREI, B ;
CERUTTI, PA .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 143 (02) :609-616
[23]  
SETTY BNY, 1987, J BIOL CHEM, V262, P17613
[24]   RELATIONSHIP BETWEEN PARATHYROID-HORMONE SECRETION AND CYTOSOLIC CALCIUM-CONCENTRATION IN DISPERSED BOVINE PARATHYROID CELLS [J].
SHOBACK, DM ;
THATCHER, J ;
LEOMBRUNO, R ;
BROWN, EM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (10) :3113-3117
[25]  
SHOBACK DM, 1991, J BONE MINER RES, V6, P207
[26]   COMPARATIVE ACTIVITY OF NATURAL MONOHYDROXY, DI-HYDROXY AND TRI-HYDROXY DERIVATIVES OF ARACHIDONIC-ACID ON GUINEA-PIG LUNGS - MYOTROPIC EFFECT AND STIMULATION OF CYCLOOXYGENASE ACTIVITY [J].
SIROIS, P ;
ROY, S ;
BERALDIN, G ;
VALLERAND, P ;
BORGEAT, P .
PROSTAGLANDINS, 1982, 24 (03) :405-418
[27]  
STENSON WF, 1979, J CLIN INVEST, V64, P1457, DOI 10.1172/JCI109604
[28]   POTENTIAL ROLE OF 12-HYDROXYEICOSATETRAENOIC ACID IN ANGIOTENSIN-II-INDUCED CALCIUM SIGNAL IN RAT GLOMERULOSA CELLS [J].
STERN, N ;
YANAGAWA, N ;
SAITO, F ;
HORI, M ;
NATARAJAN, R ;
NADLER, J ;
TUCK, M .
ENDOCRINOLOGY, 1993, 133 (02) :843-847
[29]   ARACHIDONIC-ACID METABOLISM IN ISOLATED PANCREATIC-ISLETS .3. EFFECTS OF EXOGENOUS LIPOXYGENASE PRODUCTS AND INHIBITORS ON INSULIN-SECRETION [J].
TURK, J ;
COLCA, JR ;
MCDANIEL, ML .
BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 834 (01) :23-36
[30]   COMPLEX EFFECTS OF ARACHIDONIC-ACID AND ITS LIPOXYGENASE PRODUCTS ON CYTOSOLIC CALCIUM IN GH3 CELLS [J].
VACHER, P ;
MCKENZIE, J ;
DUFY, B .
AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (05) :E903-E912