EFFECTS OF BETA-BLOCKADE ON ENERGY-METABOLISM FOLLOWING BURNS

被引：45

作者：

BREITENSTEIN, E ^{[1
]}

CHIOLERO, RL ^{[1
]}

JEQUIER, E ^{[1
]}

DAYER, P ^{[1
]}

KRUPP, S ^{[1
]}

SCHUTZ, Y ^{[1
]}

机构：

[1] INST PHYSIOL,FAC MED,RUE BUGNON 7,CH-1005 LAUSANNE,SWITZERLAND

来源：

BURNS | 1990年 / 16卷 / 04期

关键词：

D O I：

10.1016/0305-4179(90)90136-K

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The purpose of this study was to compare the effects of propranolol administered either by i.v. infusion or by prolonged oral administration (4 days) during the first 3 weeks following burns. The resting metabolic rate (RMR) of 10 non-infected fasting burned patients (TBSA: 28 per cent, range 18-37 per cent) was determined four times consecutively by indirect calorimetry (open circuit hood system) following: (1) i.v. physiological saline; (2) i.v. propranolol infusion (2 μg/kg/min following a bolus of 80 μg/kg); (3) oral propranolol (40 mg q.i.d. during 4 ± 1 days); and (4) in control patients. All patients showed large increases in both RMR (144 ± 2 per cent of reference values) and in urinary catecholamine excretion (three to four times as compared to control values). The infusion of propranolol induced a significant decrease in RMR to 135±2 per cent and oral propranolol to 129±3 per cent of reference values. A decrease in lipid oxidation but no change in carbohydrate and protein oxidation were observed during propranolol administration. It is concluded that the decrease in RMR induced by propranolol was not influenced by the route of administration. The magnitude of the decrease in energy expenditure suggests that beta-adrenergic hyperactivity represents only one of the mediators of the hypermetabolic response to burn injury. © 1990.

引用

页码：259 / 264

页数：6

共 30 条

[11]

Du Bois, The basal metabolism in fever, JAMA: The Journal of the American Medical Association, 77, (1921)

[12]

Fleisch, Le Métabolisme basal standard et se détermination au moyen du ‘Metabocalculator’, Helv. Med. Acta, 18, (1951)

[13]

Frayn, Hormonal control of metabolism in trauma and sepsis, Clin. Endocrinol., 24, (1986)

[14]

Goodall, Stone, Haynes, Urinary output of adrenaline and noradrenaline in severe thermal burns, Ann. Surg., 145, (1957)

[15]

Grande, Energy expenditure of organs and tissues, Assessment of energy metabolism in health and disease, (1980)

[16]

Harris, Benedict, Standard basal metabolism constants for physiologists and clinicians, A Biometric Study of Basal Metabolism in Man, (1919)

[17]

Hawk, Kjeldhal method, Practical Physiological Chemistry, (1919)

[18]

Herbert, Lau, Gottlieb, Coated charcoal immunoassay of insulin, J. Clin. Endocrinol. Metab., 25, (1965)

[19]

Hemdon, Barrow, Rutan, Et al., Effect of propranolol administration on hemodynamic and metabolic responses of burned pediatric patients, Ann. Surg., 208, (1988)

[20]

Jequier, The influence of nutrient administration on energy expenditure in man, Clinical Nutrition, 4, (1986)

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