CONFLICTING GASTRIC-INHIBITORY POLYPEPTIDE DATA - POSSIBLE CAUSES

被引：9

作者：

ALAM, MJ

BUCHANAN, KD

机构：

[1] KING SAUD UNIV,COLL MED,RIYADH,SAUDI ARABIA

[2] QUEENS UNIV BELFAST,BELFAST BT7 1NN,ANTRIM,NORTH IRELAND

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 1993年 / 19卷 / 02期

关键词：

DIABETES-MELLITUS; OBESITY; CHRONIC PANCREATITIS; SPECIES VARIATION; MOLECULAR HETEROGENEITY; ENTEROINSULAR AXIS;

D O I：

10.1016/0168-8227(93)90102-B

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The literature with respect to GIP is flooded with conflicting data especially with respect to its role in type 2 diabetes mellitus, obesity, type 1 diabetes mellitus and chronic pancreatitis. This review describes possible reasons for the discrepancies which include species variation of GIP, heterogeneity of molecules with different immunoreactivity and bioactivity, deterioration of immunoreactivity of standard and sample on prolonged storage and the effect of the preceding intake of type and quantity of food. The problems can be resolved by raising antibodies to synthetic human GIP and its fragments, the chemical characterization of and the raising of antibodies to immunoreactive GIP 8000, the correct storage of samples and the standard preparation of subjects prior to experimental procedures.

引用

页码：93 / 101

页数：9

共 90 条

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