CASEIN KINASE II-ALPHA TRANSGENE-INDUCED MURINE LYMPHOMA - RELATION TO THEILERIOSIS IN CATTLE

被引：356

作者：

SELDIN, DC ^{[1
]}

LEDER, P ^{[1
]}

机构：

[1] HARVARD UNIV, SCH MED, HOWARD HUGHES MED INST, DEPT GENET, BOSTON, MA 02115 USA

来源：

SCIENCE | 1995年 / 267卷 / 5199期

关键词：

D O I：

10.1126/science.7846532

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Infection of cattle with the protozoan parasite Theileria parva results in a fatal lymphoproliferative syndrome that is associated with the overexpression of casein kinase II. The role of this enzyme in the pathogenesis of lymphoproliferative disorders was investigated by expressing the catalytic subunit in lymphocytes of transgenic mice. Adult transgenic mice displayed a stochastic propensity to develop lymphoma; co-expression of a c-myc transgene in addition to casein kinase II resulted in neonatal leukemia. Thus, the casein kinase II gene can serve as an oncogene, and its dysregulated expression is capable of transforming lymphocytes in a two-step pathway with c-myc.

引用

页码：894 / 897

页数：4