THE 1ST SYNTHESIS OF THE N-GLUCOSYL ANALOG OF THE ANTITUMOR AGENT ETOPOSIDE

被引：9

作者：

ALLEVI, P

ANASTASIA, M

CIUFFREDA, P

机构：

[1] Department of Chemistry and Biochemistry, University of Milan, I-20133 Milan

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 45期

关键词：

ETOPOSIDE; AZAETOPOSIDE; ANTITUMOR; ANTICANCER; N-GLYCOSIDATION;

D O I：

10.1016/S0040-4039(00)79317-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first synthesis of 1-aminoglucose analogue of the antitumor agent etoposide is accomplished by condensation of 4,6-O-ethylidene-2,3-di-O-trimethylsilyl-beta-D-glucopyranosylamine with 4-bromo-4-deoxy-4'-demethylepipodophyllotoxin in the presence of Hg(CN)2.

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页码：7313 / 7316

页数：4

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