BETA-ANOMER SELECTIVITY IN 2'-DEOXYNUCLEOSIDE SYNTHESIS - A NOVEL-APPROACH USING AN ACYL CARBAMATE DIRECTING GROUP

被引：28

作者：

YOUNG, RJ

SHAWPONTER, S

HARDY, GW

MILLS, G

机构：

[1] Department of Medicinal Chemistry, The Wellcome Foundation Ltd., Beckenham

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 46期

关键词：

D O I：

10.1016/S0040-4039(00)78472-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Glycosylation of silylated pyrimidines using a phenyl 2-deoxy-3-O-(N-benzoyl)carbamoyl-1-thio-D-erythro-pentofuranoside yielded 2-deoxy-beta-ribonucleosides in good yields with excellent anomeric selectivity. This prototype 3-O-carbamate directing group was readily formed and removed in high yields.

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页码：8687 / 8690

页数：4

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