ASYMMETRIC-SYNTHESIS OF 3'-CARBOMETHOXYMETHYL-3'-DEOXYTHYMIDINE VIA RADICAL CYCLIZATION

被引：32

作者：

LAVALLEE, JF ^{[1
]}

JUST, G ^{[1
]}

机构：

[1] MCGILL UNIV,DEPT CHEM,MONTREAL H3A 2K6,QUEBEC,CANADA

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 29期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/0040-4039(91)80808-J

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient asymmetric synthesis of 3'-C-carbomethoxymethyl- 3'-deoxythymidine 2, using a highly stereocontrolled radical cyclization from bromoacetal 7 to furanose 8, followed by a dimethylboron bromide mediated nucleoside formation, is described. A 96:4 beta-selectivity was observed for thionoester-controlled base attachment.

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页码：3469 / 3472

页数：4

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