MISMATCH REPAIR - MECHANISMS AND RELATIONSHIP TO CANCER SUSCEPTIBILITY

被引：269

作者：

KOLODNER, RD ^{[1
]}

机构：

[1] HARVARD UNIV, SCH MED, DEPT BIOL CHEM & MOLEC PHARMACOL, BOSTON, MA 02115 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1995年 / 20卷 / 10期

关键词：

D O I：

10.1016/S0968-0004(00)89087-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA mismatch-repair systems exist that repair mispaired bases formed during DNA replication, genetic recombination and as a result of damage to DNA. Some components of these systems are conserved in prokaryotes and eukaryotes. Genetic defects in mismatch-repair genes play an important role in common cancer-susceptibility syndromes and sporadic cancers.

引用

页码：397 / 401

页数：5

共 49 条

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