NOCTURNAL INTRA-GASTRIC THERAPY IN TYPE-I GLYCOGEN-STORAGE DISEASE - EFFECT ON HORMONAL AND AMINO-ACID METABOLISM

被引：14

作者：

SLONIM, AE ^{[1
]}

LACY, WW ^{[1
]}

TERRY, A ^{[1
]}

GREENE, HL ^{[1
]}

BURR, IM ^{[1
]}

机构：

[1] VANDERBILT UNIV,SCH MED,DEPT MED,NASHVILLE,TN 37232

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 1979年 / 28卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0026-0495(79)90175-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The acute hormonal and amino acid responses to differing food substrates were examined in type I glycogen storage disease. Ingestion of a glucose load or a glucose-plus-beef meal caused an acute fall in the initially elevated plasma glucagon, alanine, proline, and lactate. Ingestion of beef alone caused a sharp rise in these parameters. Long term nocturnal intragastric therapy of a high carbohydrate and moderate amino acid content resulted in a similar fall in these parameters as well as a fall in the elevated plasma glutamate, uric acid, triglycerides, and RBC-reduced glutathione. A remarkable clinical improvement and growth spurt accompanied the improvement in these biochemical values. The possible relation between the disturbed plasma hormonal and amino acid findings and growth failure and hyperuricemia is discussed. © 1979.

引用

页码：707 / 715

页数：9

共 30 条

[21] A SIMPLE FLUORIMETRIC METHOD FOR ESTIMATION OF FREE 11-HYDROXYCORTICOIDS IN HUMAN PLASMA [J].