COMPARATIVE ANTIOXIDANT ACTIVITIES OF PROPRANOLOL, NIFEDIPINE, VERAPAMIL, AND DILTIAZEM AGAINST SARCOLEMMAL MEMBRANE LIPID-PEROXIDATION

被引：170

作者：

MAK, IT

WEGLICKI, WB

机构：

[1] Div. of Experimental Medicine, George Washington University, Medical Center, Washington, DC 20037, 2300 Eye Street, NW

来源：

CIRCULATION RESEARCH | 1990年 / 66卷 / 05期

关键词：

antiperoxidant activity; calcium-channel blockers; propranolol; sarcolemmal lipid peroxidation;

D O I：

10.1161/01.RES.66.5.1449

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The antiperoxidative activities of nifedipine, verapamil, and diltiazem were compared with that of propranolol by using an in vitro model of sarcolemmal membrane lipid peroxidation. Highly purified sarcolemmal membranes, isolated from canine ventricular myocytes, were peroxidized by a superoxide anion-producing and iron-catalyzed free radical-generating system (dihydroxy-fumarate plus FeCl3 and ADP). Lipid peroxidation after 20 minutes of incubation was monitored by malondialdehyde formation. Similar to propranolol, all three calcium blockers exhibited concentration-dependent (10-400 μM) inhibitory effects against sarcolemmal lipid peroxidation. The order of potency of these agents was nifedipine > propranolol > verapamil > diltiazem. Nifedipine, the most effective calcium blocker, was greater than twofold more potent than propranolol and achieved a significant effect at 10 μM. This study suggests that calcium blockers may provide antiperoxidative protection to cardiac membranes.

引用

页码：1449 / 1452

页数：4

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